2ver: Difference between revisions
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<StructureSection load='2ver' size='340' side='right' caption='[[2ver]], [[NMR_Ensembles_of_Models | 1 NMR models]]' scene=''> | ==Structural model for the complex between the Dr adhesins and carcinoembryonic antigen (CEA)== | ||
<StructureSection load='2ver' size='340' side='right'caption='[[2ver]], [[NMR_Ensembles_of_Models | 1 NMR models]]' scene=''> | |||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2ver]] is a 2 chain structure with sequence from [ | <table><tr><td colspan='2'>[[2ver]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895] and [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VER OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VER FirstGlance]. <br> | ||
</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MTN:S-[(1-OXYL-2,2,5,5-TETRAMETHYL-2,5-DIHYDRO-1H-PYRROL-3-YL)METHYL]+METHANESULFONOTHIOATE'>MTN</scene>< | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MTN:S-[(1-OXYL-2,2,5,5-TETRAMETHYL-2,5-DIHYDRO-1H-PYRROL-3-YL)METHYL]+METHANESULFONOTHIOATE'>MTN</scene></td></tr> | ||
<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1e07|1e07]], [[1ut2|1ut2]], [[1usz|1usz]], [[2ixq|2ixq]], [[1rxl|1rxl]]</td></tr> | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1e07|1e07]], [[1ut2|1ut2]], [[1usz|1usz]], [[2ixq|2ixq]], [[1rxl|1rxl]]</div></td></tr> | ||
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ver FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ver OCA], [https://pdbe.org/2ver PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ver RCSB], [https://www.ebi.ac.uk/pdbsum/2ver PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ver ProSAT]</span></td></tr> | ||
<table> | </table> | ||
== Function == | |||
[[https://www.uniprot.org/uniprot/AFAE3_ECOLX AFAE3_ECOLX]] Hemagglutinins of uropathogenic E.coli mediate adherence to the upper urinary tract. These adhesins bind to the Dr blood group antigen and also agglutinate human erythrocytes in the presence of D-mannose (mannose-resistant hemagglutination (MRHA)). [[https://www.uniprot.org/uniprot/CEAM5_HUMAN CEAM5_HUMAN]] Cell surface glycoprotein that plays a role in cell adhesion and in intracellular signaling. Receptor for E.coli Dr adhesins.<ref>PMID:10864933</ref> | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
Check<jmol> | Check<jmol> | ||
<jmolCheckbox> | <jmolCheckbox> | ||
<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ve/2ver_consurf.spt"</scriptWhenChecked> | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ve/2ver_consurf.spt"</scriptWhenChecked> | ||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
</jmolCheckbox> | </jmolCheckbox> | ||
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/ | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2ver ConSurf]. | ||
<div style="clear:both"></div> | <div style="clear:both"></div> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
<div class="pdbe-citations 2ver" style="background-color:#fffaf0;"></div> | |||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Bacillus coli migula 1895]] | ||
[[Category: | [[Category: Human]] | ||
[[Category: Cota, E | [[Category: Large Structures]] | ||
[[Category: Demeler, B | [[Category: Cota, E]] | ||
[[Category: Korotkova, N | [[Category: Demeler, B]] | ||
[[Category: Marchant, J | [[Category: Korotkova, N]] | ||
[[Category: Matthews, S | [[Category: Marchant, J]] | ||
[[Category: Moseley, S L | [[Category: Matthews, S]] | ||
[[Category: Stenkamp, R E | [[Category: Moseley, S L]] | ||
[[Category: Thomas, W E | [[Category: Stenkamp, R E]] | ||
[[Category: Trong, I Le | [[Category: Thomas, W E]] | ||
[[Category: Yang, Y | [[Category: Trong, I Le]] | ||
[[Category: Yang, Y]] | |||
[[Category: Cell adhesion]] | [[Category: Cell adhesion]] | ||
[[Category: Cell projection]] | [[Category: Cell projection]] | ||
