Nitric Oxide Synthase: Difference between revisions

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'''Nitric Oxide Synthase''' (NOS) is an enzyme catalysing the formation of L-citrulline and [http://en.wikipedia.org/wiki/Nitric_Oxide/ nitric oxide] (NO) from L-arginine. NOS is a homodimeric protein with 125- to 160-kDa per monomer. In mammals, NOS appears as 3 isozymes: neuronal NOS (nNOS) (for details see [[Nos1]]), cytokine-inducible NOS (iNOS) and endothelial NOS (eNOS). The N-terminal domain of NOS is an oxygenase domain (OD). NOS cofactors are: NADPH, FAD, FMN, heme and O2. See also [[Nos1]].

'''Nitric Oxide Synthase''' (NOS) or '''Nitric Oxide Synthase oxygenase''' is an enzyme catalysing the formation of L-citrulline and [http://en.wikipedia.org/wiki/Nitric_Oxide/ nitric oxide] (NO) from L-arginine. NOS is a homodimeric protein with 125- to 160-kDa per monomer. In mammals, NOS appears as 3 isozymes: neuronal NOS (nNOS) (for details see [[Nos1]]), cytokine-inducible NOS (iNOS) and endothelial NOS (eNOS). The N-terminal domain of NOS is an '''oxygenase''' domain (OD). NOS cofactors are: NADPH, FAD, FMN, heme and O2. See also [[Nos1]].

=Introduction=

Line 92:

Structures used in the section above: [[1tll]]

~~</StructureSection>~~

~~== 3D Structures of Nitric Oxide Synthase ==~~

~~Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}~~

= 3D Structures of Nitric Oxide Synthase =

~~{{#tree:id~~=~~OrganizedByTopic|openlevels~~=0|

[[Nitric Oxide Synthase 3D structures]]

*Endothelial NOS

</StructureSection>

**[[3nld]], [[3nle]], [[3nlf]], [[3nlg]], [[3jww]], [[3jwx]], [[3jwy]], [[3jwz]], [[3dqs]], [[3dqt]], [[3pnh]], [[4luw]] – b-eNOS OD+pyrrolidinomethyl pyridine derivative – bovine

**[[1dm6]] – b-eNOS OD+guanidine derivative

**[[3nlh]], [[3rqo]], [[3rqp]] – b-eNOS OD (mutant)+pyrrolidinomethyl aminopyridine derivative

**[[1rs8]], [[1rs9]], [[1p6n]] – b-eNOS OD +dipeptide inhibitor

**[[1nse]] – b-eNOS OD

**[[1p6n]] – b-eNOS OD +dipeptide inhibitor

**[[5nse]], [[1fol]], [[1foo]], [[1fop]], [[1dm7]], [[2nse]], [[3nse]], [[4nse]] – b-eNOS OD+arginine derivative

**[[6nse]] – b-eNOS OD+canavanine

**[[7nse]] – b-eNOS OD+ADMA

**[[1i83]], [[1d1v]], [[1d1x]], [[1d1y]], [[1ed4]], [[9nse]] – b-eNOS OD+urea derivative

**[[1dmj]], [[1dmk]] – b-eNOS OD+pterin derivative

**[[1foi]], [[1dmi]], [[1i83]], [[3n5p]], [[3n5q]], [[3n5r]], [[3n5s]], [[3n5t]], [[3n5v]], [[3n5w]], [[3n5x]], [[3n5y]], [[3n5z]], [[3n60]], [[3n61]], [[3n62]], [[3n63]], [[3n64]], [[3n65]], [[3n66]], [[3n67]], [[3n68]], [[3n69]], [[3n6a]], [[3n6b]], [[3n6c]], [[3n6d]], [[3n6e]], [[3n6f]], [[3n6g]], [[3nlt]], [[3nlu]], [[3e7s]], [[5vv6]], [[5vv7]], [[5vv8]], [[5vv9]], [[4upq]], [[4upr]], [[4ups]], [[4upt]], [[5vva]], [[5vvb]], [[5vvc]], [[5vvd]], [[5vvg]], [[5vvn]], [[5uo8]], [[5uo9]], [[5uoa]], [[5uob]], [[5uoc]], [[5uod]], [[5fvy]], [[5fvz]], [[5fj2]], [[5fj3]], [[5adj]], [[5adk]], [[5adl]], [[5adm]], [[5adn]], [[4uh7]], [[4uh8]], [[4uh9]], [[4uha]], [[4d33]], [[4d34]], [[4d35]], [[4d36]], [[4d37]], [[4d38]], [[4d39]], [[4d3a]], [[4cul]], [[4cum]], [[4cun]], [[4cvg]], [[4cwv]], [[4cww]], [[4cwx]], [[4cty]], [[4ctz]], [[4cu0]], [[4cu1]] – b-eNOS OD+inhibitor

**[[4cwz]], [[4cx0]], [[4cx1]], [[4cx2]] – b-eNOS OD (mutant) +inhibitor

**[[1d0c]], [[8nse]], [[1foj]], [[1ed5]], [[1d0o]], [[1d1w]] – b-eNOS OD+indazole derivative

**[[1dm8]] – b-eNOS OD+triazole derivative

**[[1ed6]] – b-eNOS OD+NO

**[[1q2o]] – b-eNOS OD (mutant)+dipeptide inhibitor

**[[1p6l]], [[1p6m]] – r-eNOS OD +dipeptide inhibitor - rat

**[[3nli]] - r-eNOS OD (mutant)+pyrrolidinomethyl aminopyridine derivative

**[[4jsk]], [[4jsl]], [[4jsm]], [[4imx]], [[4k5h]], [[4k5i]], [[4k5j]], [[4k5k]], [[4c3a]] – r-eNOS OD+ pyridine derivative

**[[4kcp]], [[4kcq]], [[4kcr]], [[4kcs]] - r-eNOS OD heme domain +thiophene carboximidamide derivative

**[[3eah]] – h-eNOS OD - human

**[[3nos]] – h-eNOS OD+arginine

**[[1m9j]] – h-eNOS OD+chlorzoxazone

**[[1m9k]], [[1m9r]], [[4d1p]] – h-eNOS OD+ inhibitor

**[[1nsi]] - h-eNOS OD+ Zn

*Neuronal NOS

**[[2hx2]] – b-nNOS OD+nitroguanidine derivative

**[[3nlv]], [[3nlw]], [[3nlx]], [[3nly]], [[3nlz]], [[3nm0]], [[4uh7]], [[4uh8]], [[4uh9]], [[4uha]] - b-nNOS OD + inhibitor

**[[3nli]], [[3nlj]], [[3nlk]], [[3nln]], [[3nlo]], [[3nlp]], [[3nlq]], [[3nlr]], [[3jws]], [[3jwt]], [[3jwu]], [[3jwv]], [[3jx0]], [[3jx1]], [[3jx2]], [[3jx3]], [[3jx4]], [[3jx5]], [[3jx6]], [[3pne]], [[3pnf]], [[3png]], [[3svp]], [[3svq]] - r-nNOS OD (mutant)+ pyridine derivative – rat

**[[3nlm]], [[3nny]], [[3nnz]], [[3n2r]], [[3b3o]], [[3b3p]], [[3b3m]], [[3b3n]], [[3rqj]], [[3rqk]], [[3rql]], [[3rqm]], [[3rqn]], [[3tyl]], [[3tym]], [[3tyn]], [[3tyo]], [[4ims]], [[4imt]], [[4imu]], [[4imw]], [[4jse]], [[4jsf]], [[4jsg]], [[4jsh]], [[4jsi]], [[4jsj]], [[4k5d]], [[4k5e]], [[4k5f]], [[4k5g]], [[4lux]] - r-nNOS OD+ pyridine derivative

**[[4gqe]] – r-nNOS OD + norvaline derivative

**[[1om4]], [[1k2r]], [[1k2s]], [[1lzx]], [[2hx4]], [[1zvl]], [[1qw6]], [[4fvw]], [[4fvx]], [[4fvy]], [[4fvz]], [[4fw0]] - r-nNOS OD+arginine derivative

**[[4cam]], [[4can]], [[4cao]], [[4cap]], [[4caq]], [[4car]], [[4cdt]], [[4cft]] – r-nNOS OD heme domain + quinoline derivative

**[[1k2t]], [[1k2u]] – r-nNOS OD+thiourea derivative

**[[1om5]] – r-nNOS OD+indazole derivative

**[[1lzz]], [[1m00]], [[2hx3]]– r-nNOS OD+guanidine derivative

**[[4kch]], [[4kci]], [[4kcj]], [[4kck]], [[4kcl]], [[4kcm]], [[4kcn]], [[4kco]] - r-nNOS OD heme domain +thiophene carboximidamide derivative

**[[3fc5]], [[1zvi]] – r-nNOS OD

**[[1qau]] - r-nNOS OD PDZ domain

**[[1qav]], [[4hop]] - r-nNOS OD PDZ domain + α-1 syntrophin

**[[1qwc]], [[3q99]], [[3q9a]], [[1mmv]], [[1mmw]], [[3dqr]], [[3ufo]], [[3ufp]], [[3ufq]], [[3ufr]], [[3ufs]], [[3uft]], [[3ufu]], [[3ufv]], [[3ufw]], [[4eux]], [[5vui]], [[4upm]], [[4upn]], [[4upo]], [[4upp]], [[5vuk]], [[5vul]], [[5vum]], [[5vun]], [[5vuo]], [[5vup]], [[5vuq]], [[5vur]], [[5vus]], [[5vut]], [[5vuu]], [[5unr]], [[5unt]], [[5unu]], [[5unv]], [[5unw]], [[5unx]], [[5uny]], [[5unz]], [[5uo0]], [[5fw0]], [[5fvo]], [[5fvp]], [[5fvq]], [[5fvr]], [[5fvs]], [[5fvt]], [[5agk]], [[5agl]], [[5agm]], [[5agn]], [[5ago]], [[5agp]], [[4v3v]], [[4v3w]], [[4v3x]], [[4v3y]], [[4v3z]], [[5ad4]], [[5ad5]], [[5ad6]], [[5ad7]], [[5ad8]], [[5ad9]], [[5ada]], [[5adb]], [[5adc]], [[4ugz]], [[4d33]], [[4d34]], [[4d35]], [[4d2y]], [[4d1z]], [[4d30]], [[4d31]], [[4uh4]], [[4d7o]], [[4d3b]], [[4d32]], [[4ctp]], [[4ctq]], [[4ctr]], [[4ctt]], [[4ctu]], [[4ctv]], [[4c39]] – r-nNOS OD+inhibitor

**[[5vv0]], [[5vv3]], [[5vv5]], [[5uns]], [[5uo1]], [[5uo2]], [[5uo3]], [[5uo4]], [[5uo5]], [[5uo6]], [[5uo7]], [[5g0n]], [[5g0p]], [[5fvu]], [[5fvv]], [[5fvx]], [[5fvw]], [[5fvx]], [[4v3u]], [[5add]], [[5ade]], [[5adf]], [[5adg]], [[5adi]], [[4cx3]], [[4cx4]], [[4cx5]], [[4cx6]] – r-nNOS OD (mutant) +inhibitor

**[[3jt3]], [[3jt4]], [[3jt5]], [[3jt6]], [[3jt7]], [[3jt8]], [[3jt9]], [[3jta]] – r-nNOS OD+ornithine derivative

**[[3hsn]] – r-nNOS OD+NHA+CO

**[[3hso]], [[3hsp]] - r-nNOS OD+NHA+NO

**[[2g6h]], [[2g6i]], [[2g6j]] – r-nNOS OD+pterin derivative

**[[2g6k]], [[2g6l]] – r-nNOS OD+pterin derivative+NO

**[[2g6m]], [[2g6n]], [[2g6o]] – r-nNOS OD+pterin derivative+CO

**[[1zzq]], [[1zzr]], [[1zzs]], [[1zzt]], [[1zzu]], [[1p6k]] – r-nNOS OD (mutant)+dipeptide inhibitor

**[[1rs6]], [[1rs7]], [[1p6h]], [[1p6i]], [[1p6j]] – r-nNOS OD +dipeptide inhibitor

**[[1b8q]] – r-nNOS PDZ domain + heptapeptide

**[[1f20]] - r-nNOS FAD/NADP domain

**[[1vag]] – m-nNOS OD+inhibitor - mouse

**[[4uh5]] - h-nNOS OD+inhibitor

**[[4uh6]], [[4uch]] - h-nNOS OD (mutant) +inhibitor

**[[4d1n]] - h-nNOS OD (mutant) + arginine

*Inducible NOS

**[[3nqs]], [[3e65]], [[3eai]], [[3ebd]], [[3ebf]], [[1r35]], [[2nod]] – m-iNOS OD + pterin derivative

**[[1jwj]], [[1jwk]] – m-iNOS OD (mutant)+ pterin derivative

**[[4ux6]] – m-iNOS OD + pterin derivative + inhibitor

**[[2bhj]] – m-iNOS OD+coumarin

**[[3nod]] – m-iNOS OD+product analog

**[[1noc]] – m-iNOS OD+chloramphenicol acetyltransferase

**[[3e67]] – m-iNOS OD+4-MAP

**[[3e68]], [[3e6l]], [[3e6n]], [[3e6o]], [[3e6t]], [[3e7i]], [[3e7m]], [[3e7t]], [[1vaf]], [[1qw5]], [[1dd7]], [[2y37]] – m-iNOS OD+inhibitor

**[[2orq]], [[2orr]], [[2ors]], [[2ort]], [[2oro]], [[2orp]], [[1nos]], [[3nw2]] – m-iNOS OD+imidazole derivative

**[[1df1]] - m-iNOS OD+ urea derivative

**[[3dwj]] – m-iNOS OD (mutant)

**[[1qom]], [[4js9]] - m-iNOS OD

**[[1qw4]], [[1dwv]], [[1dww]], [[1dwx]], [[1nod]] – m-iNOS OD+arginine derivative

**[[2nos]] – m-iNOS OD+guanidine derivative

**[[1n2n]] – m-iNOS OD+CN

**[[1m9t]] – m-iNOS OD+indazole derivative

**[[1m8d]] – m-iNOS OD+chlorzoxazone

**[[1m8e]], [[1m8h]], [[1m8i]], [[1m9m]], [[1m9q]] – m-iNOS OD+ indazole derivative

**[[1jwj]] – m-iNOS OD + inhibitor

**[[1jwk]] - m-iNOS OD (mutant) + inhibitor

**[[3hr4]] – h-iNOS residues 503-715+calmodulin – human

**[[3e7g]] – h-iNOS residues 82-505+inhibitor

**[[3ej8]] – h-iNOS OD+imidazole

**[[4nos]], [[4cx7]] – h-iNOS OD+inhibitor

**[[1nsi]] – h-iNOS OD+arginine

**[[2nsi]] – h-iNOS OD+thiourea derivative

**[[3gof]] - c-iNOS OD + calmodulin – chicken

*Prokaryote NOS

**[[2amo]] – BsNOS – ''Bacillus subtilis''

**[[2an0]], [[2an2]] – BsNOS (mutant)

**[[2fbz]], [[2fc2]], [[2fc1]] – BsNOS+NO

**[[1m7v]], [[1m7z]] – BsNOS+THF+arginine

**[[5g67]], [[4ugl]] – BsNOS + inhibitor

**[[2flq]] – NOS+arginine – ''Geobacillus stearothermophilus''

}}

==References==

[[Category:Topic Page]]

@@ Line 1: / Line 1: @@
-<StructureSection load='2g6h' size='400' side='right' caption='Neuronal nitric oxide synthase dimer complex with cofactor tetrahydrobiopterin, acetate and Zn+2 (grey), (PDB entry [[2g6h]])' scene=''>
+<StructureSection load='2g6h' size='350' side='right' caption='Neuronal nitric oxide synthase dimer complex with cofactor tetrahydrobiopterin, acetate and Zn+2 (grey), (PDB entry [[2g6h]])' scene=''>
-'''Nitric Oxide Synthase''' (NOS) is an enzyme catalysing the formation of L-citrulline and [http://en.wikipedia.org/wiki/Nitric_Oxide/ nitric oxide] (NO) from L-arginine. NOS is a homodimeric protein with 125- to 160-kDa per monomer.  In mammals, NOS appears as 3 isozymes: neuronal NOS (nNOS) (for details see [[Nos1]]), cytokine-inducible NOS (iNOS) and endothelial NOS (eNOS).  The N-terminal domain of NOS is an oxygenase domain (OD).  NOS cofactors are: NADPH, FAD, FMN, heme and O2.  See also [[Nos1]].
+'''Nitric Oxide Synthase''' (NOS) or '''Nitric Oxide Synthase oxygenase''' is an enzyme catalysing the formation of L-citrulline and [http://en.wikipedia.org/wiki/Nitric_Oxide/ nitric oxide] (NO) from L-arginine. NOS is a homodimeric protein with 125- to 160-kDa per monomer.  In mammals, NOS appears as 3 isozymes: neuronal NOS (nNOS) (for details see [[Nos1]]), cytokine-inducible NOS (iNOS) and endothelial NOS (eNOS).  The N-terminal domain of NOS is an '''oxygenase''' domain (OD).  NOS cofactors are: NADPH, FAD, FMN, heme and O2.  See also [[Nos1]].
 =Introduction=
@@ Line 92: / Line 92: @@
 Structures used in the section above: [[1tll]]
-</StructureSection>
-== 3D Structures of Nitric Oxide Synthase ==
-Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
+= 3D Structures of Nitric Oxide Synthase =
-{{#tree:id=OrganizedByTopic|openlevels=0|
+[[Nitric Oxide Synthase 3D structures]]
-*Endothelial NOS
+</StructureSection>
-**[[3nld]], [[3nle]], [[3nlf]], [[3nlg]], [[3jww]], [[3jwx]], [[3jwy]], [[3jwz]], [[3dqs]], [[3dqt]], [[3pnh]], [[4luw]] – b-eNOS OD+pyrrolidinomethyl pyridine derivative – bovine<br />
-**[[1dm6]] – b-eNOS OD+guanidine derivative<br />
-**[[3nlh]], [[3rqo]], [[3rqp]] – b-eNOS OD (mutant)+pyrrolidinomethyl aminopyridine derivative<br />
-**[[1rs8]], [[1rs9]], [[1p6n]] – b-eNOS OD +dipeptide inhibitor<br />
-**[[1nse]] – b-eNOS OD<br />
-**[[1p6n]] – b-eNOS OD +dipeptide inhibitor<br />
-**[[5nse]], [[1fol]], [[1foo]], [[1fop]], [[1dm7]], [[2nse]], [[3nse]], [[4nse]] – b-eNOS OD+arginine derivative<br />
-**[[6nse]] – b-eNOS OD+canavanine<br />
-**[[7nse]] – b-eNOS OD+ADMA<br />
-**[[1i83]], [[1d1v]], [[1d1x]], [[1d1y]], [[1ed4]], [[9nse]] – b-eNOS OD+urea derivative<br />
-**[[1dmj]], [[1dmk]] – b-eNOS OD+pterin derivative<br />
-**[[1foi]], [[1dmi]], [[1i83]], [[3n5p]], [[3n5q]], [[3n5r]], [[3n5s]], [[3n5t]], [[3n5v]], [[3n5w]], [[3n5x]], [[3n5y]], [[3n5z]], [[3n60]], [[3n61]], [[3n62]], [[3n63]], [[3n64]], [[3n65]], [[3n66]], [[3n67]], [[3n68]], [[3n69]], [[3n6a]], [[3n6b]], [[3n6c]], [[3n6d]], [[3n6e]], [[3n6f]], [[3n6g]], [[3nlt]], [[3nlu]], [[3e7s]], [[5vv6]], [[5vv7]], [[5vv8]], [[5vv9]], [[4upq]], [[4upr]], [[4ups]], [[4upt]], [[5vva]], [[5vvb]], [[5vvc]], [[5vvd]], [[5vvg]], [[5vvn]], [[5uo8]], [[5uo9]], [[5uoa]], [[5uob]], [[5uoc]], [[5uod]], [[5fvy]], [[5fvz]], [[5fj2]], [[5fj3]], [[5adj]], [[5adk]], [[5adl]], [[5adm]], [[5adn]], [[4uh7]], [[4uh8]], [[4uh9]], [[4uha]], [[4d33]], [[4d34]], [[4d35]], [[4d36]], [[4d37]], [[4d38]], [[4d39]], [[4d3a]], [[4cul]], [[4cum]], [[4cun]], [[4cvg]], [[4cwv]], [[4cww]], [[4cwx]], [[4cty]], [[4ctz]], [[4cu0]], [[4cu1]] – b-eNOS OD+inhibitor<br />
-**[[4cwz]], [[4cx0]], [[4cx1]], [[4cx2]]  – b-eNOS OD (mutant) +inhibitor<br />
-**[[1d0c]], [[8nse]], [[1foj]], [[1ed5]], [[1d0o]], [[1d1w]] – b-eNOS OD+indazole derivative<br />
-**[[1dm8]] – b-eNOS OD+triazole derivative<br />
-**[[1ed6]] – b-eNOS OD+NO<br />
-**[[1q2o]] – b-eNOS OD (mutant)+dipeptide inhibitor<br />
-**[[1p6l]], [[1p6m]] – r-eNOS OD +dipeptide inhibitor - rat<br />
-**[[3nli]] - r-eNOS OD (mutant)+pyrrolidinomethyl aminopyridine derivative<br />
-**[[4jsk]], [[4jsl]], [[4jsm]], [[4imx]], [[4k5h]], [[4k5i]], [[4k5j]], [[4k5k]], [[4c3a]] – r-eNOS OD+ pyridine derivative<br />
-**[[4kcp]], [[4kcq]], [[4kcr]], [[4kcs]] - r-eNOS OD heme domain +thiophene carboximidamide derivative<br />
-**[[3eah]] – h-eNOS OD - human<br />
-**[[3nos]] – h-eNOS OD+arginine<br />
-**[[1m9j]] – h-eNOS OD+chlorzoxazone<br />
-**[[1m9k]], [[1m9r]], [[4d1p]] – h-eNOS OD+ inhibitor<br />
-**[[1nsi]] - h-eNOS OD+ Zn
-*Neuronal NOS
-**[[2hx2]] – b-nNOS OD+nitroguanidine derivative<br />
-**[[3nlv]], [[3nlw]], [[3nlx]], [[3nly]], [[3nlz]], [[3nm0]], [[4uh7]], [[4uh8]], [[4uh9]], [[4uha]] - b-nNOS OD + inhibitor<br />
-**[[3nli]], [[3nlj]], [[3nlk]], [[3nln]], [[3nlo]], [[3nlp]], [[3nlq]], [[3nlr]], [[3jws]], [[3jwt]], [[3jwu]], [[3jwv]], [[3jx0]], [[3jx1]], [[3jx2]], [[3jx3]], [[3jx4]], [[3jx5]], [[3jx6]], [[3pne]], [[3pnf]], [[3png]], [[3svp]], [[3svq]] - r-nNOS OD (mutant)+ pyridine derivative – rat<br />
-**[[3nlm]], [[3nny]], [[3nnz]], [[3n2r]], [[3b3o]], [[3b3p]], [[3b3m]], [[3b3n]], [[3rqj]], [[3rqk]], [[3rql]], [[3rqm]], [[3rqn]], [[3tyl]], [[3tym]], [[3tyn]], [[3tyo]], [[4ims]], [[4imt]], [[4imu]], [[4imw]], [[4jse]], [[4jsf]], [[4jsg]], [[4jsh]], [[4jsi]], [[4jsj]], [[4k5d]], [[4k5e]], [[4k5f]], [[4k5g]], [[4lux]] - r-nNOS OD+ pyridine derivative<br />
-**[[4gqe]]  – r-nNOS OD + norvaline derivative<br />
-**[[1om4]], [[1k2r]], [[1k2s]], [[1lzx]], [[2hx4]], [[1zvl]], [[1qw6]], [[4fvw]], [[4fvx]], [[4fvy]], [[4fvz]], [[4fw0]] - r-nNOS OD+arginine derivative<br />
-**[[4cam]], [[4can]], [[4cao]], [[4cap]], [[4caq]], [[4car]], [[4cdt]], [[4cft]]  – r-nNOS OD heme domain + quinoline derivative<br />
-**[[1k2t]], [[1k2u]] – r-nNOS OD+thiourea derivative<br />
-**[[1om5]] – r-nNOS OD+indazole derivative<br />
-**[[1lzz]], [[1m00]], [[2hx3]]– r-nNOS OD+guanidine derivative<br />
-**[[4kch]], [[4kci]], [[4kcj]], [[4kck]], [[4kcl]], [[4kcm]], [[4kcn]], [[4kco]] - r-nNOS OD heme domain +thiophene carboximidamide derivative<br />
-**[[3fc5]], [[1zvi]] – r-nNOS OD<br />
-**[[1qau]] - r-nNOS OD PDZ domain<br />
-**[[1qav]], [[4hop]] - r-nNOS OD PDZ domain + α-1 syntrophin<br />
-**[[1qwc]], [[3q99]], [[3q9a]], [[1mmv]], [[1mmw]], [[3dqr]], [[3ufo]], [[3ufp]], [[3ufq]], [[3ufr]], [[3ufs]], [[3uft]], [[3ufu]], [[3ufv]], [[3ufw]], [[4eux]], [[5vui]], [[4upm]], [[4upn]], [[4upo]], [[4upp]], [[5vuk]], [[5vul]], [[5vum]], [[5vun]], [[5vuo]], [[5vup]], [[5vuq]], [[5vur]], [[5vus]], [[5vut]], [[5vuu]], [[5unr]], [[5unt]], [[5unu]], [[5unv]], [[5unw]], [[5unx]], [[5uny]], [[5unz]], [[5uo0]], [[5fw0]], [[5fvo]], [[5fvp]], [[5fvq]], [[5fvr]], [[5fvs]], [[5fvt]], [[5agk]], [[5agl]], [[5agm]], [[5agn]], [[5ago]], [[5agp]], [[4v3v]], [[4v3w]], [[4v3x]], [[4v3y]], [[4v3z]], [[5ad4]], [[5ad5]], [[5ad6]], [[5ad7]], [[5ad8]], [[5ad9]], [[5ada]], [[5adb]], [[5adc]], [[4ugz]], [[4d33]], [[4d34]], [[4d35]], [[4d2y]], [[4d1z]], [[4d30]], [[4d31]], [[4uh4]], [[4d7o]], [[4d3b]], [[4d32]], [[4ctp]], [[4ctq]], [[4ctr]], [[4ctt]], [[4ctu]], [[4ctv]], [[4c39]] – r-nNOS OD+inhibitor<br />
-**[[5vv0]], [[5vv3]], [[5vv5]], [[5uns]], [[5uo1]], [[5uo2]], [[5uo3]], [[5uo4]], [[5uo5]], [[5uo6]], [[5uo7]], [[5g0n]], [[5g0p]], [[5fvu]], [[5fvv]], [[5fvx]], [[5fvw]], [[5fvx]], [[4v3u]], [[5add]], [[5ade]], [[5adf]], [[5adg]], [[5adi]], [[4cx3]], [[4cx4]], [[4cx5]], [[4cx6]] – r-nNOS OD (mutant) +inhibitor<br />
-**[[3jt3]], [[3jt4]], [[3jt5]], [[3jt6]], [[3jt7]], [[3jt8]], [[3jt9]], [[3jta]] – r-nNOS OD+ornithine derivative<br />
-**[[3hsn]] – r-nNOS OD+NHA+CO<br />
-**[[3hso]], [[3hsp]] -  r-nNOS OD+NHA+NO<br />
-**[[2g6h]], [[2g6i]], [[2g6j]] – r-nNOS OD+pterin derivative<br />
-**[[2g6k]], [[2g6l]] – r-nNOS OD+pterin derivative+NO<br />
-**[[2g6m]], [[2g6n]], [[2g6o]] – r-nNOS OD+pterin derivative+CO<br />
-**[[1zzq]], [[1zzr]], [[1zzs]], [[1zzt]], [[1zzu]], [[1p6k]] – r-nNOS OD (mutant)+dipeptide inhibitor<br />
-**[[1rs6]], [[1rs7]], [[1p6h]], [[1p6i]], [[1p6j]] – r-nNOS OD +dipeptide inhibitor<br />
-**[[1b8q]] – r-nNOS PDZ domain + heptapeptide<br />
-**[[1f20]] - r-nNOS FAD/NADP domain<br />
-**[[1vag]] – m-nNOS OD+inhibitor - mouse<br />
-**[[4uh5]] - h-nNOS OD+inhibitor<br />
-**[[4uh6]], [[4uch]] - h-nNOS OD (mutant) +inhibitor<br />
-**[[4d1n]] - h-nNOS OD (mutant) + arginine<br />
-*Inducible NOS
-**[[3nqs]], [[3e65]], [[3eai]], [[3ebd]], [[3ebf]], [[1r35]], [[2nod]]  – m-iNOS OD + pterin derivative<br />
-**[[1jwj]], [[1jwk]] – m-iNOS OD (mutant)+ pterin derivative<br />
-**[[4ux6]] – m-iNOS OD + pterin derivative + inhibitor<br />
-**[[2bhj]] – m-iNOS OD+coumarin<br />
-**[[3nod]] – m-iNOS OD+product analog<br />
-**[[1noc]] – m-iNOS OD+chloramphenicol acetyltransferase<br />
-**[[3e67]] – m-iNOS OD+4-MAP<br />
-**[[3e68]], [[3e6l]], [[3e6n]], [[3e6o]], [[3e6t]], [[3e7i]], [[3e7m]], [[3e7t]], [[1vaf]], [[1qw5]], [[1dd7]], [[2y37]] – m-iNOS OD+inhibitor <br />
-**[[2orq]], [[2orr]], [[2ors]], [[2ort]], [[2oro]], [[2orp]], [[1nos]], [[3nw2]] – m-iNOS OD+imidazole derivative<br />
-**[[1df1]] - m-iNOS OD+ urea derivative<br />
-**[[3dwj]] – m-iNOS OD (mutant)<br />
-**[[1qom]], [[4js9]] - m-iNOS OD<br />
-**[[1qw4]], [[1dwv]], [[1dww]], [[1dwx]], [[1nod]] – m-iNOS OD+arginine derivative<br />
-**[[2nos]] – m-iNOS OD+guanidine derivative<br />
-**[[1n2n]] – m-iNOS OD+CN<br />
-**[[1m9t]] – m-iNOS OD+indazole derivative<br />
-**[[1m8d]] – m-iNOS OD+chlorzoxazone<br />
-**[[1m8e]], [[1m8h]], [[1m8i]], [[1m9m]], [[1m9q]] – m-iNOS OD+ indazole derivative<br />
-**[[1jwj]] – m-iNOS OD + inhibitor<br />
-**[[1jwk]] - m-iNOS OD (mutant) + inhibitor<br />
-**[[3hr4]] – h-iNOS residues 503-715+calmodulin – human<br />
-**[[3e7g]] – h-iNOS residues 82-505+inhibitor<br />
-**[[3ej8]] – h-iNOS OD+imidazole<br />
-**[[4nos]], [[4cx7]] – h-iNOS OD+inhibitor<br />
-**[[1nsi]] – h-iNOS OD+arginine<br />
-**[[2nsi]] – h-iNOS OD+thiourea derivative<br />
-**[[3gof]] - c-iNOS OD + calmodulin – chicken<br />
-*Prokaryote NOS
-**[[2amo]] – BsNOS – ''Bacillus subtilis''<br />
-**[[2an0]], [[2an2]] – BsNOS (mutant)<br />
-**[[2fbz]], [[2fc2]], [[2fc1]] – BsNOS+NO<br />
-**[[1m7v]], [[1m7z]] – BsNOS+THF+arginine<br />
-**[[5g67]], [[4ugl]] – BsNOS + inhibitor<br />
-**[[2flq]] – NOS+arginine – ''Geobacillus stearothermophilus''<br />
-}}
 ==References==
 <references/>
 [[Category:Topic Page]]

Nitric Oxide Synthase: Difference between revisions

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