Transaldolase: Difference between revisions

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{{STRUCTURE_3tno| PDB=3tno  | SIZE=400| SCENE= |right|CAPTION=Transaldolase dimer complex with sedoheptulose 7-phosphate, [[3tno]] }}
<StructureSection load='' size='400' side='right' scene='47/477090/Cv/1' caption='Transaldolase dimer complex with sedoheptulose 7-phosphate and Cl- (green) ion, [[3tno]]' pspeed='8'>
__TOC__
== Function ==
'''Transaldolase''' (TAL) is part of the pentose phosphate pathway.  It catalyzes the transformation of sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate to erythrose 4-phosphate and fructose 6-phosphate<ref>PMID:15960612</ref>.
See also [[Calvin cycle]] and [[Lysine-cysteine NOS bonds]].


'''Transaldolase''' (TAD) is part of the pentose phosphate pathway.  It catalyzes the transformation of sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate to erythrose 4-phosphate and fructose 6-phosphate.
== Disease ==
 
TAL deficiency influences mitochondrial homeostasis, Ca+2 fluxing and apoptosis<ref>PMID:18498245</ref>.
{{TOC limit|limit=2}}


== Structural highlights ==
TAL overall structure is of a <scene name='47/477090/Cv/8'>TIM barrel</scene> ({{Template:ColorKey_Helix}},
{{Template:ColorKey_Strand}},
{{Template:ColorKey_Loop}},
{{Template:ColorKey_Turn}}). The <scene name='47/477090/Cv/9'>active site contains a Schiff-base-bound phosphosugar</scene> at <scene name='47/477090/Cv/10'>Lys135</scene><ref>PMID:24531488</ref>. Water molecules are shown as red spheres. <scene name='47/477090/Cv/11'>Cl coordination site</scene>.
== 3D Structures of transaldolase ==
== 3D Structures of transaldolase ==
[[Transaldolase 3D structures]]
</StructureSection>


''Update June 2011''
== References ==
 
<references/>
[[3clm]] – TAD – ''Neisseria gonorrhoeae''<br />
[[3cwn]] – EcTAD B – ''Escherichia coli''<br />
[[3kof]] - EcTAD B (mutant)<br />
[[3hjz]] – TAD B – ''Prochlorococcus marinus''<br />
[[3igx]] – FtTAD B – ''Francisella tularensis''<br />
[[3m16]] – TAD – ''Oleispira Antarctica''
 
===Transaldolase binary complexes===
 
[[3tk7]] - FtTAD B + fructose 6-phosphate<br />
[[3te9]] - FtTAD B (mutant) + fructose 6-phosphate<br />
[[3tkf]] - FtTAD B (mutant) + seduheptulose 7-phosphate<br /`>
[[3tno]] - FtTAD B + seduheptulose 7-phosphate
 
[[Category:Topic Page]]
[[Category:Topic Page]]
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