HMG-CoA Reductase: Difference between revisions
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==Function== | ==Function== | ||
[[HMG-CoA Reductase]] (or '''3-hydroxy-3-methyl-glutaryl-CoA reductase''' or '''HMGR''') is the rate-controlling enzyme of the mevalonate pathway, responsible for cholesterol and other isoprenoid biosynthesis. HMGR is a transmembrane protein, containing 8 domains, that is anchored in the membrane of the endoplasmic reticulum.<ref name="Roitelman">PMID:1374417</ref> It is the major target of the '''Statins''' the best selling pharmaceutical drugs in the world and [[Vytorin]] - cholesterol lowering drug class . See also [[Ephrin Type-A Receptor]] | [[HMG-CoA Reductase]] (or '''3-hydroxy-3-methyl-glutaryl-CoA reductase''' or '''HMGR''') is the rate-controlling enzyme of the mevalonate pathway, responsible for cholesterol and other isoprenoid biosynthesis. HMGR is a transmembrane protein, containing 8 domains, that is anchored in the membrane of the endoplasmic reticulum.<ref name="Roitelman">PMID:1374417</ref> It is the major target of the '''Statins''' the best selling pharmaceutical drugs in the world and [[Vytorin]] - cholesterol lowering drug class . See also | ||
[[Ephrin Type-A Receptor]]<br /> | |||
[[Neurodevelopmental Disorders]]<br /> | |||
[[Mevalonate pathway]]<br /> | |||
[[Biosynthesis of cholesterol]]. | |||
[[Image: HMG-CoA_reductase_pathway.png|350px|left|thumb| Mevalonate Pathway. Note the early stage at which the statins interfere in the pathway]] | [[Image: HMG-CoA_reductase_pathway.png|350px|left|thumb| Mevalonate Pathway. Note the early stage at which the statins interfere in the pathway]] | ||
{{clear}} | {{clear}} | ||
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[[Treatments:Statin Pharmacokinetics References]]<br />. | [[Treatments:Statin Pharmacokinetics References]]<br />. | ||
<br /> | <br /> | ||
==3D Structures of HMG-CoA Reductase== | ==3D Structures of HMG-CoA Reductase== | ||
[[HMG-CoA Reductase 3D structures]] | |||
</StructureSection> | |||
==Additional Resources== | ==Additional Resources== | ||
