HMG-CoA Reductase: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older edit
Michal Harel (talk | contribs)
32,805 edits
No edit summary
Michal Harel (talk | contribs)
32,805 edits
No edit summary
 
(4 intermediate revisions by the same user not shown)
Line 7: Line 7:
==Function==
==Function==


[[HMG-CoA Reductase]] (or '''3-hydroxy-3-methyl-glutaryl-CoA reductase''' or '''HMGR''') is the rate-controlling enzyme of the mevalonate pathway, responsible for cholesterol and other isoprenoid biosynthesis. HMGR is a transmembrane protein, containing 8 domains, that is anchored in the membrane of the endoplasmic reticulum.<ref name="Roitelman">PMID:1374417</ref> It is the major target of the '''Statins''' the best selling pharmaceutical drugs in the world and [[Vytorin]] - cholesterol lowering drug class .  See also [[Ephrin Type-A Receptor]] and [[Neurodevelopmental Disorders]].
[[HMG-CoA Reductase]] (or '''3-hydroxy-3-methyl-glutaryl-CoA reductase''' or '''HMGR''') is the rate-controlling enzyme of the mevalonate pathway, responsible for cholesterol and other isoprenoid biosynthesis. HMGR is a transmembrane protein, containing 8 domains, that is anchored in the membrane of the endoplasmic reticulum.<ref name="Roitelman">PMID:1374417</ref> It is the major target of the '''Statins''' the best selling pharmaceutical drugs in the world and [[Vytorin]] - cholesterol lowering drug class .  See also  
[[Ephrin Type-A Receptor]]<br />
[[Neurodevelopmental Disorders]]<br />
[[Mevalonate pathway]]<br />
[[Biosynthesis of cholesterol]].
[[Image: HMG-CoA_reductase_pathway.png|350px|left|thumb| Mevalonate Pathway. Note the early stage at which the statins interfere in the pathway]]  
[[Image: HMG-CoA_reductase_pathway.png|350px|left|thumb| Mevalonate Pathway. Note the early stage at which the statins interfere in the pathway]]  
{{clear}}
{{clear}}
Line 62: Line 66:


</StructureSection>
</StructureSection>
==3D Structures of HMG-CoA Reductase==
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
{{#tree:id=OrganizedByTopic|openlevels=0|
*HMGCR
**[[1r7i]], [[4i64]] - PmHMGCR catalytic domain - ''Pseudomonas mevalonii'' <br/>
**[[3qae]], [[3qau]] - HMGCR (mutant) - ''Streptococcus pneumoniae'' <br/>
**[[6hr7]] - MtHMGCR – ''Methanothermococcus thermolithotrophicus''<br />
**[[6eeu]] - DaHMGCR – ''Delftiya acidovorans''<br />
*HMGCR+statins
**[[3cct]], [[3ccw]], [[3ccz]], [[3cd0]], [[3cd5]], [[3cd7]], [[3cda]], [[3cdb]], [[2r4f]], [[3bgl]], [[2q1l]], [[2q6b]], [[2q6c]], [[1hw8]], [[1hw9]], [[1hwi]], [[1hwj]], [[1hwk]], [[1hwl]] – hHMGCR catalytic domain + statin derivatives - human <br />
**[[1t02]] - PmHMGCR catalytic domain + statin derivatives <br />
*HMGCR+cofactors
**[[1dq8]] - hHMGCR catalytic domain (mutant) +CoA+HMG<br />
**[[1dq9]] - hHMGCR catalytic domain (mutant)+HMG-CoA<br />
**[[1dqa]] - hHMGCR catalytic domain (mutant)+HMG+CoA+NADP<br />
**[[1r31]] – PmHMGCR catalytic domain +CoA+mevalonate<br />
**[[1qax]], [[4i4b]] - PmHMGCR catalytic domain +HMG+CoA+NAD+<br />
**[[4i56]] - PmHMGCR catalytic domain + dithio-HMG+CoA<br />
**[[4i6a]] - PmHMGCR catalytic domain + HMG+CoA<br />
**[[4i6w]] - PmHMGCR catalytic domain + thiomevalonate<br />
**[[4i6y]] - PmHMGCR catalytic domain + mevalonate<br />
**[[6eev]] - DaHMGCR + mevalonate<br />
**[[1qay]] - PmHMGCR catalytic domain +mevalonate+NAD+<br />
**[[5wpk]] - SpHMGCR catalytic domain + HMG-CoA<br />
* HMGCR other complexes
**[[5wpj]] - SpHMGCR catalytic domain + NADP<br />
**[[6hr8]] - MtHMGCR + NADP<br />
**[[6dio]] - DaHMGCR + NAD <br />
}}


==Additional Resources==
==Additional Resources==
Retrieved from "https://proteopedia.org/HMG-CoA_Reductase"