Fibrin: Difference between revisions
From Proteopedia
Jump to navigationJump to search
Michal Harel (talk | contribs) No edit summary |
Michal Harel (talk | contribs) No edit summary |
||
| (9 intermediate revisions by 2 users not shown) | |||
| Line 1: | Line 1: | ||
<StructureSection load='1n73' size='350' side='right' scene='41/417472/Cv/3' caption='Fibrin α1 subunit (red, yellow), β subunit (cyan, blue), γ subunit (orange, magenta) from Petromyzon marinus (PDB entry [[1n73]])'> | |||
== Function == | |||
[[Fibrin]] (or Factor Ia, FIa) is a fibrous protein which when polymerized is involved in blood clotting. The polymerization epitopes of FIa are called A-knob and B-knob. [[Fibrinogen]] (Factor I, FI) is converted by thrombin to fibrin. Limited proteolysis of FI results in a fragment named D which when cross-linked by factor XIII is called double-D FIa (DDFIa) | [[Fibrin]] (or Factor Ia, FIa) is a fibrous protein which when polymerized is involved in blood clotting. The polymerization epitopes of FIa are called A-knob and B-knob. [[Fibrinogen]] (Factor I, FI) is converted by thrombin to fibrin. Limited proteolysis of FI results in a fragment named D which when cross-linked by factor XIII is called double-D FIa (DDFIa)<ref>PMID:12501189</ref>. | ||
== Disease == | |||
Overexpression of FIa can cause thrombosis. | |||
== Structural highlights == | |||
<scene name='41/417472/Cv/6'>Ca coordination site in β subunit</scene>. | |||
<scene name='41/417472/Cv/7'>Ca coordination site in γ subunit</scene> (PDB entry [[1n73]]). | |||
</StructureSection> | |||
== 3D Structures of Fibrin == | == 3D Structures of Fibrin == | ||
| Line 14: | Line 23: | ||
[[2hlo]], [[1n86]] - hFIa α, β, γ chains + peptide<br /> | [[2hlo]], [[1n86]] - hFIa α, β, γ chains + peptide<br /> | ||
[[1n8e]] - hFIa α, β, γ chains <br /> | [[1n8e]] - hFIa α, β, γ chains <br /> | ||
[[2a45]] - hFIa α, β, γ chains + thrombin<br /> | |||
[[1fzc]] – hDDFIa+peptide<br /> | |||
[[1n73]] - FIa α, β, γ chains + peptide – Sea lamprey<br /> | [[1n73]] - FIa α, β, γ chains + peptide – Sea lamprey<br /> | ||
== References == | |||
<references/> | |||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Latest revision as of 07:49, 2 March 2023
| ||||||||||||
3D Structures of Fibrin
Updated on 02-March-2023
Fibrinogen – hFIa peptide+ hFI α, β, γ chains – human
1n73, 2z4e - hFIa B-knob+ hFI α, β, γ chains
2hlo, 1n86 - hFIa α, β, γ chains + peptide
1n8e - hFIa α, β, γ chains
2a45 - hFIa α, β, γ chains + thrombin
1fzc – hDDFIa+peptide
1n73 - FIa α, β, γ chains + peptide – Sea lamprey
