Complement C4: Difference between revisions

From Proteopedia
Jump to navigationJump to search
Michal Harel (talk | contribs)
32,814 edits
New page: <StructureSection load='4fxk' size='340' side='right' caption='Human complement C4-A α chain, C4 β+γ chains (PDB code 4fxk ' scene=''> == Function == Complement C4 (CC4) is part ...
 
Joel L. Sussman (talk | contribs)
ConfirmAccount, Editor, Mutation, Print3D, Tester, Bureaucrats, journal
11,436 edits
No edit summary
 
(9 intermediate revisions by 2 users not shown)
Line 1: Line 1:
 
<StructureSection load='5jpn' size='340' side='right' caption='Glycosylated human complement C4-A α chain (grey), C4 β (green) and γ chain (pink) (PDB code [[5jpn]]) ' scene=''>
<StructureSection load='4fxk' size='340' side='right' caption='Human complement C4-A α chain, C4 β+γ chains (PDB code [[4fxk]] ' scene=''>


== Function ==
== Function ==
Line 9: Line 8:


C4 deficiency causes lupus-like autoimmunity<ref>PMID:11067882</ref>.  Copy number variations of complement C4 are associated with Behcet's disease<ref>PMID:23918728</ref>.  Level of complement C4 is associated with persistence and disease progression of chronic hepatitis C<ref>PMID:25573496</ref>.
C4 deficiency causes lupus-like autoimmunity<ref>PMID:11067882</ref>.  Copy number variations of complement C4 are associated with Behcet's disease<ref>PMID:23918728</ref>.  Level of complement C4 is associated with persistence and disease progression of chronic hepatitis C<ref>PMID:25573496</ref>.
== Relevance ==
== Structural highlights ==


</StructureSection>
</StructureSection>
Line 19: Line 14:
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}


[[5jpn]], [[5jtw]] – hCC4-A - human<br />
[[5jpn]] – hCC4a- human<br />
[[5jpm]] – hCC4-A + mannan-binding lectin serine protease<br />
[[1hzf]] – hCC4a residues 970-1336<br />
[[4xam]] – hCC4-A + hCC4-B<br />
[[5jtw]] – hCC4a residues 757-1744 + hCC4-B residues 20-675<br />  
[[4fxk]] – hCC4-A α chain + hCC4 β+γ chains<br />
[[5jpn]] – hCC4a α chain residues 680-1446 + hCC4 β residues 2—675 +γ residues 1454-1744 chains<br />  
[[4fxg]] – hCC4-A α chain + hCC4 β+γ chains + mannan-binding lectin serine protease<br />
[[5jpm]] – hCC4a α chain residues 680-1446 + hCC4 β residues 2—675 +γ residues 1454-1744 chains + mannan-binding lectin serine protease<br />  
 
[[6ysq]] – hCC4b + nanobody<br />
[[7b2m]], [[7b2p]], [[7b2q]] – hCC4b + nanobody – Cryo EM<br />
== References ==
== References ==
<references/>
<references/>
[[Category:Topic Page]]
Retrieved from "https://proteopedia.org/Complement_C4"