2nnz: Difference between revisions

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{{Seed}}
[[Image:2nnz.png|left|200px]]


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==Solution structure of the hypothetical protein AF2241 from Archaeoglobus fulgidus==
The line below this paragraph, containing "STRUCTURE_2nnz", creates the "Structure Box" on the page.
<StructureSection load='2nnz' size='340' side='right'caption='[[2nnz]]' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[2nnz]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Archaeoglobus_fulgidus_DSM_4304 Archaeoglobus fulgidus DSM 4304]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NNZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2NNZ FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2nnz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2nnz OCA], [https://pdbe.org/2nnz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2nnz RCSB], [https://www.ebi.ac.uk/pdbsum/2nnz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2nnz ProSAT]</span></td></tr>
-->
</table>
{{STRUCTURE_2nnz|  PDB=2nnz  |  SCENE=  }}
== Function ==
[https://www.uniprot.org/uniprot/O28042_ARCFU O28042_ARCFU]
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/nn/2nnz_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2nnz ConSurf].
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
AF2241 is a hypothetical protein from Archaeoglobus fulgidus and it belongs to the PFam domain of unknown function 369 (DUF369). NMR structural determination reveals that AF2241 adopts a cyclophilin-like fold, with a beta-barrel core composed of eight beta-strands, one alpha-helix, and one 3(10) helix located at each end of the barrel. The protein displays a high structural similarity to TM1367, another member of DUF369 whose structure has been determined recently by X-ray crystallography. Structural similarity search shows that AF2241 also has a high similarity to human cyclophilin A, however, sequence alignment and electrostatic potential analysis reveal that the residues in the PPIase catalytic site of human cyclophilin A are not conserved in AF2241 or TM1367. Instead, a putative active site of AF2241 maps to a negatively charged pocket composed of 9 conserved residues. Our results suggest that although AF2241 adopts the same fold as the human cyclophilin A, it may have distinct biological function.


===Solution structure of the hypothetical protein AF2241 from Archaeoglobus fulgidus===
Hypothetical protein AF2241 from Archaeoglobus fulgidus adopts a cyclophilin-like fold.,Ai X, Li L, Semesi A, Yee A, Arrowsmith CH, Li SS, Choy WY J Biomol NMR. 2007 Aug;38(4):353-8. Epub 2007 Jul 4. PMID:17610131<ref>PMID:17610131</ref>


 
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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The line below this paragraph, {{ABSTRACT_PUBMED_17610131}}, adds the Publication Abstract to the page
<div class="pdbe-citations 2nnz" style="background-color:#fffaf0;"></div>
(as it appears on PubMed at http://www.pubmed.gov), where 17610131 is the PubMed ID number.
== References ==
-->
<references/>
{{ABSTRACT_PUBMED_17610131}}
__TOC__
 
</StructureSection>
==About this Structure==
[[Category: Archaeoglobus fulgidus DSM 4304]]
2NNZ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Archaeoglobus_fulgidus Archaeoglobus fulgidus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NNZ OCA].
[[Category: Large Structures]]
 
[[Category: Ai X]]
==Reference==
[[Category: Arrowsmith CH]]
<ref group="xtra">PMID:17610131</ref><references group="xtra"/>
[[Category: Choy WY]]
[[Category: Archaeoglobus fulgidus]]
[[Category: Li SSC]]
[[Category: Ai, X.]]
[[Category: Semesib A]]
[[Category: Arrowsmith, C H.]]
[[Category: Yee A]]
[[Category: Choy, W Y.]]
[[Category: Li, S S.C.]]
[[Category: OCSP, Ontario Centre for Structural Proteomics.]]
[[Category: Semesib, A.]]
[[Category: Yee, A.]]
[[Category: Beta-barrel]]
[[Category: Ocsp]]
[[Category: Ontario centre for structural proteomic]]
[[Category: Structural genomic]]
[[Category: Unknown function]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 00:58:39 2009''

Latest revision as of 10:02, 14 June 2023

Solution structure of the hypothetical protein AF2241 from Archaeoglobus fulgidus

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