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==A C2HC zinc finger is essential for the activity of the RING ubiquitin ligase RNF125==
==A C2HC zinc finger is essential for the activity of the RING ubiquitin ligase RNF125==
<StructureSection load='5dka' size='340' side='right' caption='[[5dka]], [[Resolution|resolution]] 1.55&Aring;' scene=''>
<StructureSection load='5dka' size='340' side='right'caption='[[5dka]], [[Resolution|resolution]] 1.55&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5dka]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5DKA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5DKA FirstGlance]. <br>
<table><tr><td colspan='2'>[[5dka]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5DKA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5DKA FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.55&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5dka FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5dka OCA], [http://pdbe.org/5dka PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5dka RCSB], [http://www.ebi.ac.uk/pdbsum/5dka PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5dka ProSAT]</span></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5dka FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5dka OCA], [https://pdbe.org/5dka PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5dka RCSB], [https://www.ebi.ac.uk/pdbsum/5dka PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5dka ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
[[http://www.uniprot.org/uniprot/RN125_HUMAN RN125_HUMAN]] The disease is caused by mutations affecting the gene represented in this entry.  
[https://www.uniprot.org/uniprot/RN125_HUMAN RN125_HUMAN] The disease is caused by mutations affecting the gene represented in this entry.
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/RN125_HUMAN RN125_HUMAN]] E3 ubiquitin-protein ligase that acts as a positive regulator of T-cell activation. E3 ligase proteins mediate ubiquitination and subsequent proteasomal degradation of target proteins.<ref>PMID:15843525</ref>
[https://www.uniprot.org/uniprot/RN125_HUMAN RN125_HUMAN] E3 ubiquitin-protein ligase that acts as a positive regulator of T-cell activation. E3 ligase proteins mediate ubiquitination and subsequent proteasomal degradation of target proteins.<ref>PMID:15843525</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 5dka" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5dka" style="background-color:#fffaf0;"></div>
==See Also==
*[[Ubiquitin protein ligase 3D structures|Ubiquitin protein ligase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Bijlmakers, M J]]
[[Category: Homo sapiens]]
[[Category: Boer, D R]]
[[Category: Large Structures]]
[[Category: Coll, M]]
[[Category: Bijlmakers MJ]]
[[Category: Ligase]]
[[Category: Boer DR]]
[[Category: Ring ubiquitin ligase]]
[[Category: Coll M]]
Retrieved from "https://proteopedia.org/5dka"