5e0r: Difference between revisions

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'''Unreleased structure'''


The entry 5e0r is ON HOLD  until Sep 29 2017
==Crystal Structure of the first bromodomain of BRD4 in complex with AYC==
<StructureSection load='5e0r' size='340' side='right'caption='[[5e0r]], [[Resolution|resolution]] 1.35&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[5e0r]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5E0R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5E0R FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.352&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5J5:2-[(CHLOROACETYL)AMINO]-5-[(E)-(4-SULFOPHENYL)DIAZENYL]BENZENESULFONIC+ACID'>5J5</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5e0r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5e0r OCA], [https://pdbe.org/5e0r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5e0r RCSB], [https://www.ebi.ac.uk/pdbsum/5e0r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5e0r ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref> <ref>PMID:11733348</ref>
== Function ==
[https://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity).


Authors: Dong, J., Caflisch, A.
==See Also==
 
*[[Bromodomain-containing protein 3D structures|Bromodomain-containing protein 3D structures]]
Description: Crystal Structure of the first bromodomain of BRD4 in complex with AYC
== References ==
[[Category: Unreleased Structures]]
<references/>
[[Category: Dong, J]]
__TOC__
[[Category: Caflisch, A]]
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Caflisch A]]
[[Category: Dong J]]
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