5e4v: Difference between revisions

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<StructureSection load='5e4v' size='340' side='right'caption='[[5e4v]], [[Resolution|resolution]] 2.71&Aring;' scene=''>
<StructureSection load='5e4v' size='340' side='right'caption='[[5e4v]], [[Resolution|resolution]] 2.71&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5e4v]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Measf Measf]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5E4V OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5E4V FirstGlance]. <br>
<table><tr><td colspan='2'>[[5e4v]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Measles_virus_strain_Edmonston-B Measles virus strain Edmonston-B] and [https://en.wikipedia.org/wiki/Measles_virus_strain_Moraten Measles virus strain Moraten]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5E4V OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5E4V FirstGlance]. <br>
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">N, NP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=70146 MEASF])</td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.71&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5e4v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5e4v OCA], [http://pdbe.org/5e4v PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5e4v RCSB], [http://www.ebi.ac.uk/pdbsum/5e4v PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5e4v ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5e4v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5e4v OCA], [https://pdbe.org/5e4v PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5e4v RCSB], [https://www.ebi.ac.uk/pdbsum/5e4v PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5e4v ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/NCAP_MEASF NCAP_MEASF]] Encapsidates the genome in a ratio of 1 N per 6 ribonucleotides, protecting it from nucleases. The nucleocapsid (NC) has a helical structure with either 12.35 or 11.64 N per turn, approximately 20 nm in diameter, with a hollow central cavity approximately 5 nm in diameter. The encapsidated genomic RNA is termed the NC and serves as template for transcription and replication. During replication, encapsidation by N is coupled to RNA synthesis and all replicative products are resistant to nucleases. N is released in the blood following lysis of measles infected cells, it interacts then with human FCGR2B on immune cells, inducing apoptosis and blocking inflammatory immune response. Ntail binds to a protein on human thymic epithelial cells, termed Nucleoprotein Receptor (NR), inducing growth arrest.  
[https://www.uniprot.org/uniprot/Q77M42_MEASM Q77M42_MEASM] Essential component of the RNA polymerase and the nascent chain assembly complex. Also required during RNA synthesis.[ARBA:ARBA00002047][https://www.uniprot.org/uniprot/NCAP_MEASF NCAP_MEASF] Encapsidates the genome in a ratio of 1 N per 6 ribonucleotides, protecting it from nucleases. The nucleocapsid (NC) has a helical structure with either 12.35 or 11.64 N per turn, approximately 20 nm in diameter, with a hollow central cavity approximately 5 nm in diameter. The encapsidated genomic RNA is termed the NC and serves as template for transcription and replication. During replication, encapsidation by N is coupled to RNA synthesis and all replicative products are resistant to nucleases. N is released in the blood following lysis of measles infected cells, it interacts then with human FCGR2B on immune cells, inducing apoptosis and blocking inflammatory immune response. Ntail binds to a protein on human thymic epithelial cells, termed Nucleoprotein Receptor (NR), inducing growth arrest.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Measf]]
[[Category: Measles virus strain Edmonston-B]]
[[Category: Butcher, S J]]
[[Category: Measles virus strain Moraten]]
[[Category: Guryanov, S G]]
[[Category: Butcher SJ]]
[[Category: Kajander, T]]
[[Category: Guryanov SG]]
[[Category: Kasaragod, P]]
[[Category: Kajander T]]
[[Category: Liljeroos, L]]
[[Category: Kasaragod P]]
[[Category: Nucleocapsid protein]]
[[Category: Liljeroos L]]
[[Category: Paramyxovirus]]
[[Category: Rna-binding protein]]
[[Category: Viral protein]]
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