5ejn: Difference between revisions

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<StructureSection load='5ejn' size='340' side='right'caption='[[5ejn]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
<StructureSection load='5ejn' size='340' side='right'caption='[[5ejn]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5ejn]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5EJN OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5EJN FirstGlance]. <br>
<table><tr><td colspan='2'>[[5ejn]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5EJN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5EJN FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.703&#8491;</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Izumo1r, Folbp3, Folr4, Juno ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5ejn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ejn OCA], [http://pdbe.org/5ejn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ejn RCSB], [http://www.ebi.ac.uk/pdbsum/5ejn PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ejn ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5ejn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ejn OCA], [https://pdbe.org/5ejn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5ejn RCSB], [https://www.ebi.ac.uk/pdbsum/5ejn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5ejn ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/JUNO_MOUSE JUNO_MOUSE]] Receptor for IZUMO1 present at the cell surface of oocytes (oolemma), which is essential for gamete recognition and fertilization. The IZUMO1:IZUMO1R/JUNO interaction is a necessary adhesion event between sperm and egg that is required for fertilization but is not sufficient for cell fusion. The ligand-receptor interaction probably does not act as a membrane 'fusogen'. Does not bind folate.<ref>PMID:24739963</ref>
[https://www.uniprot.org/uniprot/JUNO_MOUSE JUNO_MOUSE] Receptor for IZUMO1 present at the cell surface of oocytes (oolemma), which is essential for gamete recognition and fertilization. The IZUMO1:IZUMO1R/JUNO interaction is a necessary adhesion event between sperm and egg that is required for fertilization but is not sufficient for cell fusion. The ligand-receptor interaction probably does not act as a membrane 'fusogen'. Does not bind folate.<ref>PMID:24739963</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Lk3 transgenic mice]]
[[Category: Mus musculus]]
[[Category: Han, L]]
[[Category: Han L]]
[[Category: Jovine, L]]
[[Category: Jovine L]]
[[Category: Nishimura, K]]
[[Category: Nishimura K]]
[[Category: Cell adhesion]]
[[Category: Egg-sperm membrane fusion]]
[[Category: Fertilization]]
[[Category: Gamete adhesion]]
[[Category: Sperm receptor]]