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==Mouse thymidylate synthase in ternary complex with FdUMP and methylenetetrahydrofolate.==
==Mouse thymidylate synthase in ternary complex with FdUMP and methylenetetrahydrofolate.==
<StructureSection load='5fct' size='340' side='right' caption='[[5fct]], [[Resolution|resolution]] 1.55&Aring;' scene=''>
<StructureSection load='5fct' size='340' side='right'caption='[[5fct]], [[Resolution|resolution]] 1.55&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5fct]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FCT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5FCT FirstGlance]. <br>
<table><tr><td colspan='2'>[[5fct]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FCT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5FCT FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=C2F:5-METHYL-5,6,7,8-TETRAHYDROFOLIC+ACID'>C2F</scene>, <scene name='pdbligand=UFP:5-FLUORO-2-DEOXYURIDINE-5-MONOPHOSPHATE'>UFP</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.55&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3ihi|3ihi]], [[4e50|4e50]], [[4eb4|4eb4]], [[4ein|4ein]], [[4ez8|4ez8]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=C2F:5-METHYL-5,6,7,8-TETRAHYDROFOLIC+ACID'>C2F</scene>, <scene name='pdbligand=UFP:5-FLUORO-2-DEOXYURIDINE-5-MONOPHOSPHATE'>UFP</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Tyms, mCG_11630 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5fct FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fct OCA], [https://pdbe.org/5fct PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5fct RCSB], [https://www.ebi.ac.uk/pdbsum/5fct PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5fct ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5fct FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fct OCA], [http://pdbe.org/5fct PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5fct RCSB], [http://www.ebi.ac.uk/pdbsum/5fct PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5fct ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/TYSY_MOUSE TYSY_MOUSE] Contributes to the de novo mitochondrial thymidylate biosynthesis pathway (By similarity).


==See Also==
==See Also==
*[[Thymidylate synthase|Thymidylate synthase]]
*[[Thymidylate synthase 3D structures|Thymidylate synthase 3D structures]]
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Lk3 transgenic mice]]
[[Category: Large Structures]]
[[Category: Dowiercial, A]]
[[Category: Mus musculus]]
[[Category: Jarmula, A]]
[[Category: Dowiercial A]]
[[Category: Rode, W]]
[[Category: Jarmula A]]
[[Category: Wilk, P]]
[[Category: Rode W]]
[[Category: Cofactor]]
[[Category: Wilk P]]
[[Category: Complex]]
[[Category: Enzyme]]
[[Category: Inhibitor]]
[[Category: Transferase]]
Retrieved from "https://proteopedia.org/5fct"