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==Structural insight into the enzymatic mechanism of the phophothreonine lyase==
==Structural insight into the enzymatic mechanism of the phophothreonine lyase==
<StructureSection load='2q8y' size='340' side='right' caption='[[2q8y]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
<StructureSection load='2q8y' size='340' side='right'caption='[[2q8y]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2q8y]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Salmonella_enterica_subsp._enterica_serovar_enteritidis Salmonella enterica subsp. enterica serovar enteritidis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Q8Y OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2Q8Y FirstGlance]. <br>
<table><tr><td colspan='2'>[[2q8y]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Salmonella_enterica_subsp._enterica_serovar_Enteritidis Salmonella enterica subsp. enterica serovar Enteritidis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Q8Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2Q8Y FirstGlance]. <br>
</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=PTR:O-PHOSPHOTYROSINE'>PTR</scene>, <scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">mkaD, spvC, vsdD ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=149539 Salmonella enterica subsp. enterica serovar Enteritidis])</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PTR:O-PHOSPHOTYROSINE'>PTR</scene>, <scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Mitogen-activated_protein_kinase Mitogen-activated protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.24 2.7.11.24] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2q8y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2q8y OCA], [https://pdbe.org/2q8y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2q8y RCSB], [https://www.ebi.ac.uk/pdbsum/2q8y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2q8y ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2q8y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2q8y OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2q8y RCSB], [http://www.ebi.ac.uk/pdbsum/2q8y PDBsum]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/VRP3_SALEN VRP3_SALEN]] Not known. This protein is involved in the virulence of salmonellas.  
[https://www.uniprot.org/uniprot/SPVC_SALEN SPVC_SALEN] Secreted effector that irreversibly inactivates host MAP kinases by catalyzing the dephosphorylation of the phosphothreonine residue in the pT-X-pY motif present in MAPKs, via a beta-elimination reaction leading to a dehydrobutyrine residue.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
<div class="pdbe-citations 2q8y" style="background-color:#fffaf0;"></div>
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Mitogen-activated protein kinase]]
[[Category: Homo sapiens]]
[[Category: Salmonella enterica subsp. enterica serovar enteritidis]]
[[Category: Large Structures]]
[[Category: Shao, F]]
[[Category: Salmonella enterica subsp. enterica serovar Enteritidis]]
[[Category: Wang, D C]]
[[Category: Shao F]]
[[Category: Zhu, Y Q]]
[[Category: Wang D-C]]
[[Category: Alpha/beta fold]]
[[Category: Zhu Y-Q]]
[[Category: Lyase-transferase complex]]
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