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==The GTPase domains of the immunity-related Irga6 dimerize in a parallel head-to-head fashion==
==The GTPase domains of the immunity-related Irga6 dimerize in a parallel head-to-head fashion==
<StructureSection load='5fph' size='340' side='right' caption='[[5fph]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
<StructureSection load='5fph' size='340' side='right'caption='[[5fph]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5fph]] is a 7 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FPH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5FPH FirstGlance]. <br>
<table><tr><td colspan='2'>[[5fph]] is a 7 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FPH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5FPH FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GNP:PHOSPHOAMINOPHOSPHONIC+ACID-GUANYLATE+ESTER'>GNP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.2&#8491;</td></tr>
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GNP:PHOSPHOAMINOPHOSPHONIC+ACID-GUANYLATE+ESTER'>GNP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5fph FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fph OCA], [http://pdbe.org/5fph PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5fph RCSB], [http://www.ebi.ac.uk/pdbsum/5fph PDBsum]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5fph FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fph OCA], [https://pdbe.org/5fph PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5fph RCSB], [https://www.ebi.ac.uk/pdbsum/5fph PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5fph ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/IIGP1_MOUSE IIGP1_MOUSE]] GTPase with low activity. Has higher affinity for GDP than for GTP. Plays a role in resistance to intracellular pathogens. Required for disruption of the parasitophorous vacuole formed following T.gondii infection and subsequent killing of the parasite. Mediates resistance to C.trachomatis infection by targeting bacterial inclusions to autophagosomes for subsequent lysosomal destruction.<ref>PMID:11907101</ref> <ref>PMID:16304607</ref> <ref>PMID:19242543</ref> <ref>PMID:12732635</ref>
[https://www.uniprot.org/uniprot/IIGP1_MOUSE IIGP1_MOUSE] GTPase with low activity. Has higher affinity for GDP than for GTP. Plays a role in resistance to intracellular pathogens. Required for disruption of the parasitophorous vacuole formed following T.gondii infection and subsequent killing of the parasite. Mediates resistance to C.trachomatis infection by targeting bacterial inclusions to autophagosomes for subsequent lysosomal destruction.<ref>PMID:11907101</ref> <ref>PMID:16304607</ref> <ref>PMID:19242543</ref> <ref>PMID:12732635</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Daumke, O]]
[[Category: Large Structures]]
[[Category: Faelber, K]]
[[Category: Mus musculus]]
[[Category: Froehlich, C]]
[[Category: Daumke O]]
[[Category: Howard, J]]
[[Category: Faelber K]]
[[Category: Pawlowski, N]]
[[Category: Froehlich C]]
[[Category: Schulte, K]]
[[Category: Howard J]]
[[Category: Dynamin superfamily]]
[[Category: Pawlowski N]]
[[Category: Gmppnp]]
[[Category: Schulte K]]
[[Category: Gtpase]]
[[Category: Hydrolase]]
[[Category: Innate immunity]]
[[Category: Irg protein]]
[[Category: Irga6]]
[[Category: Oligomerization]]
Retrieved from "https://proteopedia.org/5fph"