1onz: Difference between revisions
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==Oxalyl-aryl-Amino Benzoic acid Inhibitors of PTP1B, compound 8b== | ==Oxalyl-aryl-Amino Benzoic acid Inhibitors of PTP1B, compound 8b== | ||
<StructureSection load='1onz' size='340' side='right' caption='[[1onz]], [[Resolution|resolution]] 2.40Å' scene=''> | <StructureSection load='1onz' size='340' side='right'caption='[[1onz]], [[Resolution|resolution]] 2.40Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1onz]] is a 1 chain structure with sequence from [ | <table><tr><td colspan='2'>[[1onz]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ONZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ONZ FirstGlance]. <br> | ||
</td></tr><tr><td class="sblockLbl"><b>[[ | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4Å</td></tr> | ||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=968:2-[(7-HYDROXY-NAPHTHALEN-1-YL)-OXALYL-AMINO]-BENZOIC+ACID'>968</scene></td></tr> | |||
<tr><td class="sblockLbl"><b>[[ | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1onz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1onz OCA], [https://pdbe.org/1onz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1onz RCSB], [https://www.ebi.ac.uk/pdbsum/1onz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1onz ProSAT]</span></td></tr> | ||
</table> | |||
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | == Function == | ||
<table> | [https://www.uniprot.org/uniprot/PTN1_HUMAN PTN1_HUMAN] Tyrosine-protein phosphatase which acts as a regulator of endoplasmic reticulum unfolded protein response. Mediates dephosphorylation of EIF2AK3/PERK; inactivating the protein kinase activity of EIF2AK3/PERK. May play an important role in CKII- and p60c-src-induced signal transduction cascades. May regulate the EFNA5-EPHA3 signaling pathway which modulates cell reorganization and cell-cell repulsion.<ref>PMID:21135139</ref> <ref>PMID:22169477</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
Check<jmol> | Check<jmol> | ||
<jmolCheckbox> | <jmolCheckbox> | ||
<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/on/1onz_consurf.spt"</scriptWhenChecked> | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/on/1onz_consurf.spt"</scriptWhenChecked> | ||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
</jmolCheckbox> | </jmolCheckbox> | ||
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/ | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1onz ConSurf]. | ||
<div style="clear:both"></div> | <div style="clear:both"></div> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
<div class="pdbe-citations 1onz" style="background-color:#fffaf0;"></div> | |||
==See Also== | ==See Also== | ||
*[[Tyrosine phosphatase|Tyrosine phosphatase]] | *[[Tyrosine phosphatase 3D structures|Tyrosine phosphatase 3D structures]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
| Line 35: | Line 37: | ||
</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: Abad-Zapatero | [[Category: Abad-Zapatero C]] | ||
[[Category: Ballaron | [[Category: Ballaron SJ]] | ||
[[Category: Fesik | [[Category: Fesik SW]] | ||
[[Category: Hadjuk | [[Category: Hadjuk PJ]] | ||
[[Category: Hutchins | [[Category: Hutchins CW]] | ||
[[Category: Janowich | [[Category: Janowich DA]] | ||
[[Category: Jirousek | [[Category: Jirousek MR]] | ||
[[Category: Liang | [[Category: Liang H]] | ||
[[Category: Liu | [[Category: Liu G]] | ||
[[Category: Lubben | [[Category: Lubben T]] | ||
[[Category: Mika | [[Category: Mika AK]] | ||
[[Category: Pei | [[Category: Pei Z]] | ||
[[Category: Stashko | [[Category: Stashko MA]] | ||
[[Category: Szczepankiewicz | [[Category: Szczepankiewicz BG]] | ||
[[Category: Trevillyan | [[Category: Trevillyan JM]] | ||
[[Category: Xin | [[Category: Xin Z]] | ||
[[Category: Zinker | [[Category: Zinker BA]] | ||
Latest revision as of 09:29, 16 August 2023
Oxalyl-aryl-Amino Benzoic acid Inhibitors of PTP1B, compound 8b
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