2x7h: Difference between revisions

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~~'''Unreleased structure'''~~

~~The entry~~ 2x7h is ~~ON HOLD~~

==Crystal structure of the human MGC45594 gene product in complex with fenoprofen==

~~Authors~~: ~~Shafqat~~, N., ~~Yue~~, W.W., ~~Ugochukwu~~, E., ~~Niesen, F~~.~~, Vollmar, M~~.~~, Chaikuad, A~~., ~~Pike, A~~.C.W., ~~vonDelft, F~~.~~, Smee, C~~.~~, Arrowsmith, C~~., ~~Weigelt~~, J.~~, Edwards, A~~., Bountra, C., Oppermann, U.

== Structural highlights ==

<table><tr><td colspan='2'>[[2x7h]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X7H OCA]. For a guided tour on the structure components use [https://proteopedia.org/fgij/fg.htm?mol=2X7H FirstGlance].

~~Description~~: ~~Crystal structure of the human MGC45594 gene product in complex with fenoprofen~~

</td></tr><tr id='method'><td class="sblockLbl">[[Empirical_models|Method:]]</td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6Å</td></tr>

<tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene>, <scene name='pdbligand=PFN:FENOPROFEN'>PFN</scene></td></tr>

~~''Page seeded by~~ [~~http~~:~~//oca.weizmann.ac.il/oca OCA~~ ] ~~on Wed Mar 10 13~~:00:~~24 2010''~~

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[https://proteopedia.org/fgij/fg.htm?mol=2x7h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2x7h OCA], [https://pdbe.org/2x7h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2x7h RCSB], [https://www.ebi.ac.uk/pdbsum/2x7h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2x7h ProSAT]</td></tr>

</table>

== Function ==

[https://www.uniprot.org/uniprot/PTGR3_HUMAN PTGR3_HUMAN] Functions as 15-oxo-prostaglandin 13-reductase and acts on 15-keto-PGE1, 15-keto-PGE2, 15-keto-PGE1-alpha and 15-keto-PGE2-alpha with highest efficiency towards 15-keto-PGE2-alpha. Overexpression represses transcriptional activity of PPARG and inhibits adipocyte differentiation.[UniProtKB:Q8BGC4]

__TOC__

</StructureSection>

[[Category: Homo sapiens]]

[[Category: Large Structures]]

[[Category: Arrowsmith C]]

[[Category: Bountra C]]

[[Category: Chaikuad A]]

[[Category: Edwards A]]

[[Category: Niesen F]]

[[Category: Oppermann U]]

[[Category: Pike ACW]]

[[Category: Shafqat N]]

[[Category: Smee C]]

[[Category: Ugochukwu E]]

[[Category: Vollmar M]]

[[Category: Weigelt J]]

[[Category: Yue WW]]

[[Category: Von Delft F]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 2x7h is ON HOLD
+==Crystal structure of the human MGC45594 gene product in complex with fenoprofen==
+<StructureSection load='2x7h' size='340' side='right'caption='[[2x7h]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
-Authors: Shafqat, N., Yue, W.W., Ugochukwu, E., Niesen, F., Vollmar, M., Chaikuad, A., Pike, A.C.W., vonDelft, F., Smee, C., Arrowsmith, C., Weigelt, J., Edwards, A., Bountra, C., Oppermann, U.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[2x7h]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X7H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2X7H FirstGlance]. <br>
-Description: Crystal structure of the human MGC45594 gene product in complex with fenoprofen
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene>, <scene name='pdbligand=PFN:FENOPROFEN'>PFN</scene></td></tr>
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Mar 10 13:00:24 2010''
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2x7h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2x7h OCA], [https://pdbe.org/2x7h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2x7h RCSB], [https://www.ebi.ac.uk/pdbsum/2x7h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2x7h ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/PTGR3_HUMAN PTGR3_HUMAN] Functions as 15-oxo-prostaglandin 13-reductase and acts on 15-keto-PGE1, 15-keto-PGE2, 15-keto-PGE1-alpha and 15-keto-PGE2-alpha with highest efficiency towards 15-keto-PGE2-alpha. Overexpression represses transcriptional activity of PPARG and inhibits adipocyte differentiation.[UniProtKB:Q8BGC4]
+__TOC__
+</StructureSection>
+[[Category: Homo sapiens]]
+[[Category: Large Structures]]
+[[Category: Arrowsmith C]]
+[[Category: Bountra C]]
+[[Category: Chaikuad A]]
+[[Category: Edwards A]]
+[[Category: Niesen F]]
+[[Category: Oppermann U]]
+[[Category: Pike ACW]]
+[[Category: Shafqat N]]
+[[Category: Smee C]]
+[[Category: Ugochukwu E]]
+[[Category: Vollmar M]]
+[[Category: Weigelt J]]
+[[Category: Yue WW]]
+[[Category: Von Delft F]]