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[[Image:2b1h.gif|left|200px]]
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{{STRUCTURE_2b1h|  PDB=2b1h  |  SCENE=  }}
'''Crystal structure analysis of anti-HIV-1 V3 Fab 2219 in complex with UG29 peptide'''


==Crystal structure analysis of anti-HIV-1 V3 Fab 2219 in complex with UG29 peptide==
<StructureSection load='2b1h' size='340' side='right'caption='[[2b1h]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2b1h]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B1H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2B1H FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2b1h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2b1h OCA], [https://pdbe.org/2b1h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2b1h RCSB], [https://www.ebi.ac.uk/pdbsum/2b1h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2b1h ProSAT]</span></td></tr>
</table>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/b1/2b1h_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2b1h ConSurf].
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Human monoclonal antibody 2219 is a neutralizing antibody isolated from a human immunodeficiency virus type 1-infected individual. 2219 was originally selected for binding to a V3 fusion protein and can neutralize primary isolates from subtypes B, A, and F. Thus, 2219 represents a cross-reactive, human anti-V3 antibody. Fab 2219 binds to one face of the variable V3 beta-hairpin, primarily contacting conserved residues on the N-terminal beta-strand of V3, leaving the V3 crown or tip largely accessible. Three V3/2219 complexes reveal the antibody-bound conformations for both the N- and C-terminal regions that flank the V3 crown and illustrate how twisting of the V3 loop alters the relative dispositions and pairing of the amino acids in the adjacent V3 beta-strands and how the antibody can accommodate V3 loops with different sequences.


==Overview==
Crystal structures of human immunodeficiency virus type 1 (HIV-1) neutralizing antibody 2219 in complex with three different V3 peptides reveal a new binding mode for HIV-1 cross-reactivity.,Stanfield RL, Gorny MK, Zolla-Pazner S, Wilson IA J Virol. 2006 Jun;80(12):6093-105. PMID:16731948<ref>PMID:16731948</ref>
Human monoclonal antibody 2219 is a neutralizing antibody isolated from a human immunodeficiency virus type 1-infected individual. 2219 was originally selected for binding to a V3 fusion protein and can neutralize primary isolates from subtypes B, A, and F. Thus, 2219 represents a cross-reactive, human anti-V3 antibody. Fab 2219 binds to one face of the variable V3 beta-hairpin, primarily contacting conserved residues on the N-terminal beta-strand of V3, leaving the V3 crown or tip largely accessible. Three V3/2219 complexes reveal the antibody-bound conformations for both the N- and C-terminal regions that flank the V3 crown and illustrate how twisting of the V3 loop alters the relative dispositions and pairing of the amino acids in the adjacent V3 beta-strands and how the antibody can accommodate V3 loops with different sequences.


==About this Structure==
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
2B1H is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B1H OCA].
</div>
<div class="pdbe-citations 2b1h" style="background-color:#fffaf0;"></div>


==Reference==
==See Also==
Crystal structures of human immunodeficiency virus type 1 (HIV-1) neutralizing antibody 2219 in complex with three different V3 peptides reveal a new binding mode for HIV-1 cross-reactivity., Stanfield RL, Gorny MK, Zolla-Pazner S, Wilson IA, J Virol. 2006 Jun;80(12):6093-105. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16731948 16731948]
*[[Antibody 3D structures|Antibody 3D structures]]
*[[3D structures of human antibody|3D structures of human antibody]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Gorny, M K.]]
[[Category: Gorny MK]]
[[Category: Stanfield, R L.]]
[[Category: Stanfield RL]]
[[Category: Wilson, I A.]]
[[Category: Wilson IA]]
[[Category: Zolla-Pazner, S.]]
[[Category: Zolla-Pazner S]]
[[Category: Fab-peptide complex]]
[[Category: Gp120]]
[[Category: Hiv-1]]
[[Category: V3 loop]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 19:44:06 2008''

Latest revision as of 07:32, 23 August 2023

Crystal structure analysis of anti-HIV-1 V3 Fab 2219 in complex with UG29 peptide

2b1h, resolution 2.00Å

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