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==STRUCTURE OF GLPG IN COMPLEX WITH A MECHANISM-BASED ISOCOUMARIN INHIBITOR==
 
<StructureSection load='2xow' size='340' side='right' caption='[[2xow]], [[Resolution|resolution]] 2.09&Aring;' scene=''>
==Structure of GlpG in complex with a mechanism-based isocoumarin inhibitor==
<StructureSection load='2xow' size='340' side='right'caption='[[2xow]], [[Resolution|resolution]] 2.09&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2xow]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. The August 2011 RCSB PDB [http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Rhomboid Protease GlpG''  by David Goodsell is [http://dx.doi.org/10.2210/rcsb_pdb/mom_2011_8 10.2210/rcsb_pdb/mom_2011_8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XOW OCA]. <br>
<table><tr><td colspan='2'>[[2xow]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. The August 2011 RCSB PDB [https://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Rhomboid Protease GlpG''  by David Goodsell is [https://dx.doi.org/10.2210/rcsb_pdb/mom_2011_8 10.2210/rcsb_pdb/mom_2011_8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XOW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XOW FirstGlance]. <br>
</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BNG:B-NONYLGLUCOSIDE'>BNG</scene>, <scene name='pdbligand=ISM:5-AMINO-2-(2-METHOXY-2-OXOETHYL)BENZOIC+ACID'>ISM</scene><br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.09&#8491;</td></tr>
<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2ic8|2ic8]], [[2xov|2xov]], [[2irv|2irv]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BNG:B-NONYLGLUCOSIDE'>BNG</scene>, <scene name='pdbligand=ISM:5-AMINO-2-(2-METHOXY-2-OXOETHYL)BENZOIC+ACID'>ISM</scene></td></tr>
<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xow FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xow OCA], [https://pdbe.org/2xow PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xow RCSB], [https://www.ebi.ac.uk/pdbsum/2xow PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xow ProSAT]</span></td></tr>
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xow FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xow OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2xow RCSB], [http://www.ebi.ac.uk/pdbsum/2xow PDBsum]</span></td></tr>
</table>
<table>
== Function ==
[https://www.uniprot.org/uniprot/GLPG_ECOLI GLPG_ECOLI] Rhomboid-type serine protease that catalyzes intramembrane proteolysis.<ref>PMID:17099694</ref> <ref>PMID:16216077</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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The structural basis for catalysis and substrate specificity of a rhomboid protease.,Vinothkumar KR, Strisovsky K, Andreeva A, Christova Y, Verhelst S, Freeman M EMBO J. 2010 Oct 1. PMID:20890268<ref>PMID:20890268</ref>
The structural basis for catalysis and substrate specificity of a rhomboid protease.,Vinothkumar KR, Strisovsky K, Andreeva A, Christova Y, Verhelst S, Freeman M EMBO J. 2010 Oct 1. PMID:20890268<ref>PMID:20890268</ref>


From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
<div class="pdbe-citations 2xow" style="background-color:#fffaf0;"></div>
==See Also==
*[[Rhomboid protease|Rhomboid protease]]
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
[[Category: Large Structures]]
[[Category: RCSB PDB Molecule of the Month]]
[[Category: RCSB PDB Molecule of the Month]]
[[Category: Rhomboid Protease GlpG]]
[[Category: Rhomboid Protease GlpG]]
[[Category: Rhomboid protease]]
[[Category: Andreeva A]]
[[Category: Andreeva, A.]]
[[Category: Christova Y]]
[[Category: Christova, Y.]]
[[Category: Freeman M]]
[[Category: Freeman, M.]]
[[Category: Strisovsky K]]
[[Category: Strisovsky, K.]]
[[Category: Verhelst S]]
[[Category: Verhelst, S.]]
[[Category: Vinothkumar KR]]
[[Category: Vinothkumar, K R.]]
[[Category: Hydrolase]]
[[Category: Intramembrane protease]]
[[Category: Membrane protein]]
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