2xpv: Difference between revisions
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< | ==TetR(D) in complex with minocycline and magnesium.== | ||
<StructureSection load='2xpv' size='340' side='right'caption='[[2xpv]], [[Resolution|resolution]] 1.49Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[2xpv]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XPV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XPV FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.49Å</td></tr> | |||
--> | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=MIY:(4S,4AS,5AR,12AS)-4,7-BIS(DIMETHYLAMINO)-3,10,12,12A-TETRAHYDROXY-1,11-DIOXO-1,4,4A,5,5A,6,11,12A-OCTAHYDROTETRACENE-2-CARBOXAMIDE'>MIY</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xpv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xpv OCA], [https://pdbe.org/2xpv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xpv RCSB], [https://www.ebi.ac.uk/pdbsum/2xpv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xpv ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/TETR4_ECOLX TETR4_ECOLX] TetR is the repressor of the tetracycline resistance element; its N-terminal region forms a helix-turn-helix structure and binds DNA. Binding of tetracycline to TetR reduces the repressor affinity for the tetracycline resistance gene (tetA) promoter operator sites. | |||
== | ==See Also== | ||
*[[Tetracycline repressor protein 3D structures|Tetracycline repressor protein 3D structures]] | |||
__TOC__ | |||
</StructureSection> | |||
[[ | |||
< | |||
[[Category: Escherichia coli]] | [[Category: Escherichia coli]] | ||
[[Category: Dalm | [[Category: Large Structures]] | ||
[[Category: Hinrichs | [[Category: Dalm D]] | ||
[[Category: Palm | [[Category: Hinrichs W]] | ||
[[Category: Proft | [[Category: Palm GJ]] | ||
[[Category: Proft J]] | |||
Latest revision as of 08:02, 23 August 2023
TetR(D) in complex with minocycline and magnesium.
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