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==Crystal Structure of anti-IL-15 Antibody in Complex with human IL-15==
==Crystal Structure of anti-IL-15 Antibody in Complex with human IL-15==
<StructureSection load='2xqb' size='340' side='right' caption='[[2xqb]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
<StructureSection load='2xqb' size='340' side='right'caption='[[2xqb]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2xqb]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XQB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2XQB FirstGlance]. <br>
<table><tr><td colspan='2'>[[2xqb]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XQB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XQB FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xqb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xqb OCA], [http://pdbe.org/2xqb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2xqb RCSB], [http://www.ebi.ac.uk/pdbsum/2xqb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2xqb ProSAT]</span></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xqb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xqb OCA], [https://pdbe.org/2xqb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xqb RCSB], [https://www.ebi.ac.uk/pdbsum/2xqb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xqb ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/IL15_HUMAN IL15_HUMAN]] Cytokine that stimulates the proliferation of T-lymphocytes. Stimulation by IL-15 requires interaction of IL-15 with components of IL-2R, including IL-2R beta and probably IL-2R gamma but not IL-2R alpha.  
[https://www.uniprot.org/uniprot/IL15_HUMAN IL15_HUMAN] Cytokine that stimulates the proliferation of T-lymphocytes. Stimulation by IL-15 requires interaction of IL-15 with components of IL-2R, including IL-2R beta and probably IL-2R gamma but not IL-2R alpha.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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==See Also==
==See Also==
*[[Interleukin|Interleukin]]
*[[Interleukin 3D structures|Interleukin 3D structures]]
*[[Monoclonal Antibodies 3D structures|Monoclonal Antibodies 3D structures]]
*[[Monoclonal Antibodies 3D structures|Monoclonal Antibodies 3D structures]]
== References ==
== References ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Anderson, M]]
[[Category: Large Structures]]
[[Category: Buchanan, C]]
[[Category: Anderson M]]
[[Category: Cochrane, D]]
[[Category: Buchanan C]]
[[Category: Cruwys, S]]
[[Category: Cochrane D]]
[[Category: Ferraro, F]]
[[Category: Cruwys S]]
[[Category: Finch, D K]]
[[Category: Ferraro F]]
[[Category: Gerhardt, S]]
[[Category: Finch DK]]
[[Category: Hargreaves, D]]
[[Category: Gerhardt S]]
[[Category: Lowe, D C]]
[[Category: Hargreaves D]]
[[Category: Mallinder, P R]]
[[Category: Lowe DC]]
[[Category: Pattison, D V]]
[[Category: Mallinder PR]]
[[Category: Pauptit, R A]]
[[Category: Pattison DV]]
[[Category: Popovic, B]]
[[Category: Pauptit RA]]
[[Category: Sleeman, M]]
[[Category: Popovic B]]
[[Category: StGallay, S]]
[[Category: Sleeman M]]
[[Category: Vaughan, T J]]
[[Category: StGallay S]]
[[Category: Vousden, K]]
[[Category: Vaughan TJ]]
[[Category: Ward, A]]
[[Category: Vousden K]]
[[Category: Wilkinson, T]]
[[Category: Ward A]]
[[Category: Affinity maturation]]
[[Category: Wilkinson T]]
[[Category: Immune system]]
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