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==CRYSTAL STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS PHOSPHORIBOSYL ISOMERASE (VARIANT D11N) WITH BOUND PRFAR==
==CRYSTAL STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS PHOSPHORIBOSYL ISOMERASE (VARIANT D11N) WITH BOUND PRFAR==
<StructureSection load='2y88' size='340' side='right' caption='[[2y88]], [[Resolution|resolution]] 1.33&Aring;' scene=''>
<StructureSection load='2y88' size='340' side='right'caption='[[2y88]], [[Resolution|resolution]] 1.33&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2y88]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Y88 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2Y88 FirstGlance]. <br>
<table><tr><td colspan='2'>[[2y88]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Y88 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2Y88 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2ER:[(2R,3S,4R,5R)-5-[4-AMINOCARBONYL-5-[[(Z)-[(3R,4R)-3,4-DIHYDROXY-2-OXO-5-PHOSPHONOOXY-PENTYL]IMINOMETHYL]AMINO]IMIDAZOL-1-YL]-3,4-DIHYDROXY-OXOLAN-2-YL]METHYL+DIHYDROGEN+PHOSPHATE'>2ER</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.33&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2y85|2y85]], [[2y89|2y89]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2ER:[(2R,3S,4R,5R)-5-[4-AMINOCARBONYL-5-[[(Z)-[(3R,4R)-3,4-DIHYDROXY-2-OXO-5-PHOSPHONOOXY-PENTYL]IMINOMETHYL]AMINO]IMIDAZOL-1-YL]-3,4-DIHYDROXY-OXOLAN-2-YL]METHYL+DIHYDROGEN+PHOSPHATE'>2ER</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2y88 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2y88 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2y88 RCSB], [http://www.ebi.ac.uk/pdbsum/2y88 PDBsum]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2y88 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2y88 OCA], [https://pdbe.org/2y88 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2y88 RCSB], [https://www.ebi.ac.uk/pdbsum/2y88 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2y88 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/HIS4_MYCTU HIS4_MYCTU]] Involved in both the histidine and tryptophan biosynthetic pathways.  
[https://www.uniprot.org/uniprot/HIS4_MYCTU HIS4_MYCTU] Involved in both the histidine and tryptophan biosynthetic pathways.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
<div class="pdbe-citations 2y88" style="background-color:#fffaf0;"></div>
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Mycobacterium tuberculosis]]
[[Category: Large Structures]]
[[Category: Due, A V]]
[[Category: Mycobacterium tuberculosis H37Rv]]
[[Category: Geerlof, A]]
[[Category: Due AV]]
[[Category: Kuper, J]]
[[Category: Geerlof A]]
[[Category: Wilmanns, M]]
[[Category: Kuper J]]
[[Category: Aromatic amino acid biosynthesis]]
[[Category: Wilmanns M]]
[[Category: Histidine biosynthesis]]
[[Category: Isomerase]]
[[Category: Tim-barrel]]
[[Category: Tryptophan biosynthesis]]