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[[Image:2f8a.png|left|200px]]


{{STRUCTURE_2f8a|  PDB=2f8a  |  SCENE=  }}
==Crystal structure of the selenocysteine to glycine mutant of human glutathione peroxidase 1==
 
<StructureSection load='2f8a' size='340' side='right'caption='[[2f8a]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
===Crystal structure of the selenocysteine to glycine mutant of human glutathione peroxidase 1===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[2f8a]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F8A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2F8A FirstGlance]. <br>
{{ABSTRACT_PUBMED_016754991}}
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5&#8491;</td></tr>
 
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MLA:MALONIC+ACID'>MLA</scene></td></tr>
==About this Structure==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2f8a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2f8a OCA], [https://pdbe.org/2f8a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2f8a RCSB], [https://www.ebi.ac.uk/pdbsum/2f8a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2f8a ProSAT]</span></td></tr>
[[2f8a]] is a 2 chain structure of [[Glutathione peroxidase]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F8A OCA].  
</table>
== Function ==
[https://www.uniprot.org/uniprot/GPX1_HUMAN GPX1_HUMAN] Protects the hemoglobin in erythrocytes from oxidative breakdown.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/f8/2f8a_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2f8a ConSurf].
<div style="clear:both"></div>


==See Also==
==See Also==
*[[Glutathione peroxidase|Glutathione peroxidase]]
*[[Glutathione peroxidase|Glutathione peroxidase]]
 
__TOC__
==Reference==
</StructureSection>
<ref group="xtra">PMID:016754991</ref><references group="xtra"/>
[[Category: Glutathione peroxidase]]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Delft, F von.]]
[[Category: Large Structures]]
[[Category: Edwards, A.]]
[[Category: Edwards A]]
[[Category: Gileadi, O.]]
[[Category: Gileadi O]]
[[Category: Johansson, C.]]
[[Category: Johansson C]]
[[Category: Kavanagh, K L.]]
[[Category: Kavanagh KL]]
[[Category: Oppermann, U.]]
[[Category: Oppermann U]]
[[Category: SGC, Structural Genomics Consortium.]]
[[Category: Smee C]]
[[Category: Smee, C.]]
[[Category: Sundstrom M]]
[[Category: Sundstrom, M.]]
[[Category: Weigelt J]]
[[Category: Weigelt, J.]]
[[Category: Von Delft F]]
[[Category: Oxidoreductase]]
[[Category: Sgc]]
[[Category: Structural genomic]]
[[Category: Structural genomics consortium]]
[[Category: Thioredoxin fold]]
Retrieved from "https://proteopedia.org/2f8a"