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[[Image:2igb.jpg|left|200px]]


{{Structure
==Crystal Structure of PyrR, The Regulator Of The Pyrimidine Biosynthetic Operon In Bacillus caldolyticus, UMP-bound form==
|PDB= 2igb |SIZE=350|CAPTION= <scene name='initialview01'>2igb</scene>, resolution 1.68&Aring;
<StructureSection load='2igb' size='340' side='right'caption='[[2igb]], [[Resolution|resolution]] 1.68&Aring;' scene=''>
|SITE=  
== Structural highlights ==
|LIGAND= <scene name='pdbligand=U5P:URIDINE-5'-MONOPHOSPHATE'>U5P</scene> and <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>
<table><tr><td colspan='2'>[[2igb]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_caldolyticus Bacillus caldolyticus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IGB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2IGB FirstGlance]. <br>
|ACTIVITY= [http://en.wikipedia.org/wiki/Uracil_phosphoribosyltransferase Uracil phosphoribosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.9 2.4.2.9]  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.68&#8491;</td></tr>
|GENE= pyrR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1394 Bacillus caldolyticus])
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=U5P:URIDINE-5-MONOPHOSPHATE'>U5P</scene></td></tr>
}}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2igb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2igb OCA], [https://pdbe.org/2igb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2igb RCSB], [https://www.ebi.ac.uk/pdbsum/2igb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2igb ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/PYRR_BACCL PYRR_BACCL] Regulates transcriptional attenuation of the pyrimidine nucleotide (pyr) operon by binding in a uridine-dependent manner to specific sites on pyr mRNA. This disrupts an antiterminator hairpin in the RNA and favors formation of a downstream transcription terminator, leading to a reduced expression of downstream genes (Probable). Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ig/2igb_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2igb ConSurf].
<div style="clear:both"></div>


'''Crystal Structure of PyrR, The Regulator Of The Pyrimidine Biosynthetic Operon In Bacillus caldolyticus, UMP-bound form'''
==See Also==
 
*[[Phosphoribosyltransferase 3D structures|Phosphoribosyltransferase 3D structures]]
 
__TOC__
==About this Structure==
</StructureSection>
2IGB is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Bacillus_caldolyticus Bacillus caldolyticus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IGB OCA].
[[Category: Large Structures]]
[[Category: Bacillus caldolyticus]]
[[Category: Chander P]]
[[Category: Single protein]]
[[Category: Smith JL]]
[[Category: Uracil phosphoribosyltransferase]]
[[Category: Switzer RL]]
[[Category: Chander, P.]]
[[Category: Smith, J L.]]
[[Category: Switzer, R L.]]
[[Category: EDO]]
[[Category: U5P]]
[[Category: attenuation protein]]
[[Category: prtase]]
[[Category: pyrimidine biosynthesis]]
[[Category: rna-binding]]
[[Category: transcription]]
[[Category: transcription regulation]]
[[Category: transferase]]
[[Category: uracil phosphoribosyltransferase]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 17:29:11 2008''

Latest revision as of 10:10, 30 August 2023

Crystal Structure of PyrR, The Regulator Of The Pyrimidine Biosynthetic Operon In Bacillus caldolyticus, UMP-bound form

2igb, resolution 1.68Å

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