2ihc: Difference between revisions

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{{Seed}}
[[Image:2ihc.png|left|200px]]


<!--
==Crystal structure of the bric-a-brac (BTB) domain of human BACH1==
The line below this paragraph, containing "STRUCTURE_2ihc", creates the "Structure Box" on the page.
<StructureSection load='2ihc' size='340' side='right'caption='[[2ihc]], [[Resolution|resolution]] 2.44&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[2ihc]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IHC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2IHC FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.44&#8491;</td></tr>
-->
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ihc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ihc OCA], [https://pdbe.org/2ihc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ihc RCSB], [https://www.ebi.ac.uk/pdbsum/2ihc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ihc ProSAT]</span></td></tr>
{{STRUCTURE_2ihc|  PDB=2ihc  |  SCENE=  }}
</table>
 
== Function ==
===Crystal structure of the bric-a-brac (BTB) domain of human BACH1===
[https://www.uniprot.org/uniprot/BACH1_HUMAN BACH1_HUMAN] Transcriptional regulator that acts as repressor or activator. Binds, in vitro, to NF-E2 binding sites. Play important roles in coordinating transcription activation and repression by MAFK.
 
== Evolutionary Conservation ==
 
[[Image:Consurf_key_small.gif|200px|right]]
==Disease==
Check<jmol>
Known disease associated with this structure: Breast cancer, early-onset OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=605882 605882]], Fanconi anemia, complementation group J OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=605882 605882]]
  <jmolCheckbox>
 
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ih/2ihc_consurf.spt"</scriptWhenChecked>
==About this Structure==
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
2IHC is a 4 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IHC OCA].  
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2ihc ConSurf].
<div style="clear:both"></div>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Amos, A L.]]
[[Category: Large Structures]]
[[Category: Arrowsmith, C.]]
[[Category: Amos AL]]
[[Category: Bullock, A.]]
[[Category: Arrowsmith C]]
[[Category: Bunkoczi, G.]]
[[Category: Bullock A]]
[[Category: Delft, F von.]]
[[Category: Bunkoczi G]]
[[Category: Edwards, A.]]
[[Category: Edwards A]]
[[Category: Gorrec, F.]]
[[Category: Gorrec F]]
[[Category: Knapp, S.]]
[[Category: Knapp S]]
[[Category: Papagrigoriou, E.]]
[[Category: Papagrigoriou E]]
[[Category: SGC, Structural Genomics Consortium.]]
[[Category: Sundstrom M]]
[[Category: Sundstrom, M.]]
[[Category: Turnbull AP]]
[[Category: Turnbull, A P.]]
[[Category: Umeano C]]
[[Category: Umeano, C.]]
[[Category: Weigelt J]]
[[Category: Weigelt, J.]]
[[Category: Von Delft F]]
[[Category: Bach1]]
[[Category: Bric-a-brac domain,transcription factor]]
[[Category: Cap'n'collar type of basic region leucine zipper factor family]]
[[Category: Protein-protein interaction]]
[[Category: Sgc]]
[[Category: Structural genomic]]
[[Category: Structural genomics consortium]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 15:09:27 2009''

Latest revision as of 10:11, 30 August 2023

Crystal structure of the bric-a-brac (BTB) domain of human BACH1

2ihc, resolution 2.44Å

Drag the structure with the mouse to rotate

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