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[[Image:2o3k.gif|left|200px]]


{{Structure
==Yeast Cytosine Deaminase D92E Triple Mutant bound to transition state analogue HPY==
|PDB= 2o3k |SIZE=350|CAPTION= <scene name='initialview01'>2o3k</scene>, resolution 2.300&Aring;
<StructureSection load='2o3k' size='340' side='right'caption='[[2o3k]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
|SITE=  
== Structural highlights ==
|LIGAND= <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=HPY:4-HYDROXY-3,4-DIHYDRO-1H-PYRIMIDIN-2-ONE'>HPY</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>
<table><tr><td colspan='2'>[[2o3k]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2O3K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2O3K FirstGlance]. <br>
|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Cytosine_deaminase Cytosine deaminase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.4.1 3.5.4.1] </span>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
|GENE= FCY1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 Saccharomyces cerevisiae])
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=HPY:4-HYDROXY-3,4-DIHYDRO-1H-PYRIMIDIN-2-ONE'>HPY</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
|DOMAIN=
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2o3k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2o3k OCA], [https://pdbe.org/2o3k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2o3k RCSB], [https://www.ebi.ac.uk/pdbsum/2o3k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2o3k ProSAT]</span></td></tr>
|RELATEDENTRY=[[1ysb|1YSB]]
</table>
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2o3k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2o3k OCA], [http://www.ebi.ac.uk/pdbsum/2o3k PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2o3k RCSB]</span>
== Function ==
}}
[https://www.uniprot.org/uniprot/FCY1_YEAST FCY1_YEAST] Converts cytosine to uracil or 5-methylcytosine to thymine by deaminating carbon number 4.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/o3/2o3k_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2o3k ConSurf].
<div style="clear:both"></div>


'''Yeast Cytosine Deaminase D92E Triple Mutant bound to transition state analogue HPY'''
==See Also==
 
*[[Deaminase 3D structures|Deaminase 3D structures]]
 
__TOC__
==About this Structure==
</StructureSection>
2O3K is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2O3K OCA].
[[Category: Large Structures]]
[[Category: Cytosine deaminase]]
[[Category: Saccharomyces cerevisiae]]
[[Category: Saccharomyces cerevisiae]]
[[Category: Single protein]]
[[Category: Korkegian AM]]
[[Category: Korkegian, A M.]]
[[Category: Stoddard BL]]
[[Category: Stoddard, B L.]]
[[Category: homodimer]]
[[Category: hydrolase]]
[[Category: transition state analogue]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 04:12:13 2008''
Retrieved from "https://proteopedia.org/2o3k"