2oby: Difference between revisions
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==Crystal structure of Human P53 inducible oxidoreductase (TP53I3,PIG3)== | |||
<StructureSection load='2oby' size='340' side='right'caption='[[2oby]], [[Resolution|resolution]] 3.00Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[2oby]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OBY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2OBY FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr> | |||
== | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2oby FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2oby OCA], [https://pdbe.org/2oby PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2oby RCSB], [https://www.ebi.ac.uk/pdbsum/2oby PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2oby ProSAT]</span></td></tr> | ||
[[2oby]] is a 5 chain structure with sequence from [ | </table> | ||
== Function == | |||
== | [https://www.uniprot.org/uniprot/QORX_HUMAN QORX_HUMAN] May be involved in the generation of reactive oxygen species (ROS). Has low NADPH-dependent beta-naphthoquinone reductase activity, with a preference for 1,2-beta-naphthoquinone over 1,4-beta-naphthoquinone. Has low NADPH-dependent diamine reductase activity (in vitro).<ref>PMID:19349281</ref> | ||
< | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | |||
Check<jmol> | |||
<jmolCheckbox> | |||
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ob/2oby_consurf.spt"</scriptWhenChecked> | |||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | |||
<text>to colour the structure by Evolutionary Conservation</text> | |||
</jmolCheckbox> | |||
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2oby ConSurf]. | |||
<div style="clear:both"></div> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: | [[Category: Arrowsmith CH]] | ||
[[Category: | [[Category: Debreczeni J]] | ||
[[Category: Edwards | [[Category: Edwards A]] | ||
[[Category: Farres | [[Category: Farres J]] | ||
[[Category: Fita | [[Category: Fita I]] | ||
[[Category: Gileadi | [[Category: Gileadi O]] | ||
[[Category: Haroniti | [[Category: Haroniti A]] | ||
[[Category: Johansson | [[Category: Johansson C]] | ||
[[Category: Oppermann | [[Category: Oppermann U]] | ||
[[Category: Pares | [[Category: Pares X]] | ||
[[Category: Pike | [[Category: Pike ACW]] | ||
[[Category: Porte | [[Category: Porte S]] | ||
[[Category: Shafqat | [[Category: Shafqat N]] | ||
[[Category: Sundstrom | [[Category: Sundstrom M]] | ||
[[Category: Valencia | [[Category: Valencia E]] | ||
[[Category: Weigelt | [[Category: Weigelt J]] | ||
[[Category: | [[Category: Von Delft F]] | ||
Latest revision as of 10:34, 30 August 2023
Crystal structure of Human P53 inducible oxidoreductase (TP53I3,PIG3)
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