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[[Image:2qdf.jpg|left|200px]]


{{Structure
==Structure of N-terminal domain of E. Coli YaeT==
|PDB= 2qdf |SIZE=350|CAPTION= <scene name='initialview01'>2qdf</scene>, resolution 2.200&Aring;
<StructureSection load='2qdf' size='340' side='right'caption='[[2qdf]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
|SITE=  
== Structural highlights ==
|LIGAND= <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>
<table><tr><td colspan='2'>[[2qdf]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QDF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2QDF FirstGlance]. <br>
|ACTIVITY=
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
|GENE= yaeT ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli])
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
|DOMAIN=
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2qdf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qdf OCA], [https://pdbe.org/2qdf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2qdf RCSB], [https://www.ebi.ac.uk/pdbsum/2qdf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2qdf ProSAT]</span></td></tr>
|RELATEDENTRY=[[2qcz|2QCZ]]
</table>
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2qdf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qdf OCA], [http://www.ebi.ac.uk/pdbsum/2qdf PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2qdf RCSB]</span>
== Function ==
}}
[https://www.uniprot.org/uniprot/BAMA_ECOLI BAMA_ECOLI] Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane. Constitutes, with BamD, the core component of the assembly machinery.<ref>PMID:15951436</ref> <ref>PMID:16102012</ref> <ref>PMID:16824102</ref> <ref>PMID:20378773</ref> <ref>PMID:21823654</ref>
 
== Evolutionary Conservation ==
'''Structure of N-terminal domain of E. Coli YaeT'''
[[Image:Consurf_key_small.gif|200px|right]]
 
Check<jmol>
 
  <jmolCheckbox>
==Overview==
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/qd/2qdf_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2qdf ConSurf].
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Integral beta-barrel proteins are found in the outer membranes of mitochondria, chloroplasts, and Gram-negative bacteria. The machine that assembles these proteins contains an integral membrane protein, called YaeT in Escherichia coli, which has one or more polypeptide transport-associated (POTRA) domains. The crystal structure of a periplasmic fragment of YaeT reveals the POTRA domain fold and suggests a model for how POTRA domains can bind different peptide sequences, as required for a machine that handles numerous beta-barrel protein precursors. Analysis of POTRA domain deletions shows which are essential and provides a view of the spatial organization of this assembly machine.
Integral beta-barrel proteins are found in the outer membranes of mitochondria, chloroplasts, and Gram-negative bacteria. The machine that assembles these proteins contains an integral membrane protein, called YaeT in Escherichia coli, which has one or more polypeptide transport-associated (POTRA) domains. The crystal structure of a periplasmic fragment of YaeT reveals the POTRA domain fold and suggests a model for how POTRA domains can bind different peptide sequences, as required for a machine that handles numerous beta-barrel protein precursors. Analysis of POTRA domain deletions shows which are essential and provides a view of the spatial organization of this assembly machine.


==About this Structure==
Structure and function of an essential component of the outer membrane protein assembly machine.,Kim S, Malinverni JC, Sliz P, Silhavy TJ, Harrison SC, Kahne D Science. 2007 Aug 17;317(5840):961-4. PMID:17702946<ref>PMID:17702946</ref>
2QDF is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QDF OCA].


==Reference==
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
Structure and function of an essential component of the outer membrane protein assembly machine., Kim S, Malinverni JC, Sliz P, Silhavy TJ, Harrison SC, Kahne D, Science. 2007 Aug 17;317(5840):961-4. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17702946 17702946]
</div>
[[Category: Escherichia coli]]
<div class="pdbe-citations 2qdf" style="background-color:#fffaf0;"></div>
[[Category: Single protein]]
[[Category: Harrison, S C.]]
[[Category: Kahne, D.]]
[[Category: Kim, S.]]
[[Category: Malinverni, J C.]]
[[Category: Silhavy, T J.]]
[[Category: Sliz, P.]]
[[Category: membrane protein]]
[[Category: potra domain]]
[[Category: protein transport]]


''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 04:47:56 2008''
==See Also==
*[[Bam complex 3D structures|Bam complex 3D structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Escherichia coli K-12]]
[[Category: Large Structures]]
[[Category: Harrison SC]]
[[Category: Kahne D]]
[[Category: Kim S]]
[[Category: Malinverni JC]]
[[Category: Silhavy TJ]]
[[Category: Sliz P]]
Retrieved from "https://proteopedia.org/2qdf"