3b5n: Difference between revisions

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{{Seed}}
[[Image:3b5n.png|left|200px]]


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==Structure of the yeast plasma membrane SNARE complex==
The line below this paragraph, containing "STRUCTURE_3b5n", creates the "Structure Box" on the page.
<StructureSection load='3b5n' size='340' side='right'caption='[[3b5n]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[3b5n]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3B5N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3B5N FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3b5n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3b5n OCA], [https://pdbe.org/3b5n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3b5n RCSB], [https://www.ebi.ac.uk/pdbsum/3b5n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3b5n ProSAT]</span></td></tr>
{{STRUCTURE_3b5n|  PDB=3b5n  |  SCENE=  }}
</table>
== Function ==
[https://www.uniprot.org/uniprot/SNC1_YEAST SNC1_YEAST] SNC1 and SNC2 are vesicle-targeting proteins essential for normal secretory traffic between the Golgi and the plasma membrane. They may also be involved in vesicle fusion.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/b5/3b5n_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3b5n ConSurf].
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
SNARE proteins form a complex that leads to membrane fusion between vesicles, organelles, and plasma membrane in all eukaryotic cells. We report the 1.7A resolution structure of the SNARE complex that mediates exocytosis at the plasma membrane in the yeast Saccharomyces cerevisiae. Similar to its neuronal and endosomal homologues, the S. cerevisiae SNARE complex forms a parallel four-helix bundle in the center of which is an ionic layer. The S. cerevisiae SNARE complex exhibits increased helix bending near the ionic layer, contains water-filled cavities in the complex core, and exhibits reduced thermal stability relative to mammalian SNARE complexes. Mutagenesis experiments suggest that the water-filled cavities contribute to the lower stability of the S. cerevisiae complex.


===Structure of the yeast plasma membrane SNARE complex===
The structure of the yeast plasma membrane SNARE complex reveals destabilizing water-filled cavities.,Strop P, Kaiser SE, Vrljic M, Brunger AT J Biol Chem. 2008 Jan 11;283(2):1113-9. Epub 2007 Oct 22. PMID:17956869<ref>PMID:17956869</ref>


 
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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<div class="pdbe-citations 3b5n" style="background-color:#fffaf0;"></div>
(as it appears on PubMed at http://www.pubmed.gov), where 17956869 is the PubMed ID number.
== References ==
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<references/>
{{ABSTRACT_PUBMED_17956869}}
__TOC__
 
</StructureSection>
==About this Structure==
[[Category: Large Structures]]
3B5N is a 12 chains structure of sequences from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3B5N OCA].
 
==Reference==
<ref group="xtra">PMID:17956869</ref><references group="xtra"/>
[[Category: Saccharomyces cerevisiae]]
[[Category: Saccharomyces cerevisiae]]
[[Category: Brunger, A T.]]
[[Category: Brunger AT]]
[[Category: Strop, P.]]
[[Category: Strop P]]
[[Category: Coiled coil]]
[[Category: Lipoprotein]]
[[Category: Membrane]]
[[Category: Membrane protein]]
[[Category: Palmitate]]
[[Category: Phosphorylation]]
[[Category: Protein transport]]
[[Category: Sec9]]
[[Category: Sec9p]]
[[Category: Snap-25]]
[[Category: Snare complex]]
[[Category: Snc1]]
[[Category: Snc1p]]
[[Category: Sso1]]
[[Category: Sso1p]]
[[Category: Synaptobrevin]]
[[Category: Syntaxin]]
[[Category: Transmembrane]]
[[Category: Transport]]
[[Category: Ubl conjugation]]
 
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Retrieved from "https://proteopedia.org/3b5n"