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New page: left|200px<br /><applet load="3byi" size="350" color="white" frame="true" align="right" spinBox="true" caption="3byi, resolution 2.250Å" /> '''Crystal structure o...
 
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[[Image:3byi.jpg|left|200px]]<br /><applet load="3byi" size="350" color="white" frame="true" align="right" spinBox="true"
caption="3byi, resolution 2.250&Aring;" />
'''Crystal structure of human Rho GTPase activating protein 15 (ARHGAP15)'''<br />


==About this Structure==
==Crystal structure of human Rho GTPase activating protein 15 (ARHGAP15)==
3BYI is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BYI OCA].  
<StructureSection load='3byi' size='340' side='right'caption='[[3byi]], [[Resolution|resolution]] 2.25&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[3byi]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BYI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3BYI FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.25&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3byi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3byi OCA], [https://pdbe.org/3byi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3byi RCSB], [https://www.ebi.ac.uk/pdbsum/3byi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3byi ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/RHG15_HUMAN RHG15_HUMAN] GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Has activity toward RAC1. Overexpression results in an increase in actin stress fibers and cell contraction.<ref>PMID:12650940</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/by/3byi_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3byi ConSurf].
<div style="clear:both"></div>
 
==See Also==
*[[Rho GTPase activating protein 3D structures|Rho GTPase activating protein 3D structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Arrowsmith, C H.]]
[[Category: Arrowsmith CH]]
[[Category: Burgess-Brown, N.]]
[[Category: Burgess-Brown N]]
[[Category: Delft, F von.]]
[[Category: Doyle D]]
[[Category: Doyle, D.]]
[[Category: Edwards AM]]
[[Category: Edwards, A M.]]
[[Category: Elkins J]]
[[Category: Elkins, J.]]
[[Category: Johansson C]]
[[Category: Johansson, C.]]
[[Category: Kavanagh K]]
[[Category: Kavanagh, K.]]
[[Category: Papagrigoriou E]]
[[Category: Papagrigoriou, E.]]
[[Category: Pike ACW]]
[[Category: Pike, A C.W.]]
[[Category: Shrestha L]]
[[Category: SGC, Structural Genomics Consortium.]]
[[Category: Tickle J]]
[[Category: Shrestha, L.]]
[[Category: Ugochukwu E]]
[[Category: Tickle, J.]]
[[Category: Uppenberg J]]
[[Category: Ugochukwu, E.]]
[[Category: Weigelt J]]
[[Category: Uppenberg, J.]]
[[Category: Von Delft F]]
[[Category: Weigelt, J.]]
[[Category: arhgap15]]
[[Category: bm046]]
[[Category: rho gtpase]]
[[Category: sgc]]
[[Category: signaling protein]]
[[Category: structural genomics consortium]]
 
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Retrieved from "https://proteopedia.org/3byi"