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[[Image:3cbq.jpg|left|200px]]


{{Structure
==Crystal structure of the human REM2 GTPase with bound GDP==
|PDB= 3cbq |SIZE=350|CAPTION= <scene name='initialview01'>3cbq</scene>, resolution 1.820&Aring;
<StructureSection load='3cbq' size='340' side='right'caption='[[3cbq]], [[Resolution|resolution]] 1.82&Aring;' scene=''>
|SITE= <scene name='pdbsite=AC1:Mg+Binding+Site+For+Residue+A+301'>AC1</scene>, <scene name='pdbsite=AC2:Gdp+Binding+Site+For+Residue+A+302'>AC2</scene>, <scene name='pdbsite=AC3:Edo+Binding+Site+For+Residue+A+303'>AC3</scene>, <scene name='pdbsite=AC4:Edo+Binding+Site+For+Residue+A+304'>AC4</scene> and <scene name='pdbsite=AC5:Unx+Binding+Site+For+Residue+A+1'>AC5</scene>
== Structural highlights ==
|LIGAND= <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=GDP:GUANOSINE-5&#39;-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene> and <scene name='pdbligand=UNX:UNKNOWN ATOM OR ION'>UNX</scene>
<table><tr><td colspan='2'>[[3cbq]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CBQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3CBQ FirstGlance]. <br>
|ACTIVITY=  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.82&#8491;</td></tr>
|GENE= REM2, GI:134105571 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
}}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3cbq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cbq OCA], [https://pdbe.org/3cbq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3cbq RCSB], [https://www.ebi.ac.uk/pdbsum/3cbq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3cbq ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/REM2_HUMAN REM2_HUMAN] Binds GTP saturably and exhibits a low intrinsic rate of GTP hydrolysis (By similarity).
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cb/3cbq_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3cbq ConSurf].
<div style="clear:both"></div>


'''Crystal structure of the human REM2 GTPase with bound GDP'''
==See Also==
 
*[[GTP-binding protein 3D structures|GTP-binding protein 3D structures]]
 
__TOC__
==About this Structure==
</StructureSection>
3CBQ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CBQ OCA].
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Arrowsmith, C H.]]
[[Category: Arrowsmith CH]]
[[Category: Bochkarev, A.]]
[[Category: Bochkarev A]]
[[Category: Bountra, C.]]
[[Category: Bountra C]]
[[Category: Edwards, A M.]]
[[Category: Edwards AM]]
[[Category: MacKenzie, F.]]
[[Category: MacKenzie F]]
[[Category: Nedyalkova, L.]]
[[Category: Nedyalkova L]]
[[Category: Park, H.]]
[[Category: Park H]]
[[Category: SGC, Structural Genomics Consortium.]]
[[Category: Shen Y]]
[[Category: Shen, Y.]]
[[Category: Tempel W]]
[[Category: Tempel, W.]]
[[Category: Tong Y]]
[[Category: Tong, Y.]]
[[Category: Weigelt J]]
[[Category: Weigelt, J.]]
[[Category: EDO]]
[[Category: GDP]]
[[Category: MG]]
[[Category: UNX]]
[[Category: flj38964a]]
[[Category: gdp]]
[[Category: gtp-binding]]
[[Category: membrane]]
[[Category: nucleotide binding protein]]
[[Category: nucleotide-binding]]
[[Category: sgc]]
[[Category: structural genomics consortium]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 23 16:01:56 2008''

Latest revision as of 12:25, 30 August 2023

Crystal structure of the human REM2 GTPase with bound GDP

3cbq, resolution 1.82Å

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