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{{Seed}}
[[Image:2bj6.png|left|200px]]


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==Crystal Structure of a decameric HNA-RNA hybrid==
The line below this paragraph, containing "STRUCTURE_2bj6", creates the "Structure Box" on the page.
<StructureSection load='2bj6' size='340' side='right'caption='[[2bj6]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[2bj6]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BJ6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2BJ6 FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=6HA:1,5-ANHYDRO-2,3-DIDEOXY-2-(ADENIN-9-YL)-6-O-PHOSPHORYL-D-ARABINO-HEXITOL'>6HA</scene>, <scene name='pdbligand=6HC:1,5-ANHYDRO-2,3-DIDEOXY-2-(CYTOSIN-1-YL)-6-O-PHOSPHORYL-D-ARABINO-HEXITOL'>6HC</scene>, <scene name='pdbligand=6HG:1,5-ANHYDRO-2,3-DIDEOXY-2-(GUANIN-9-YL)-6-O-PHOSPHORYL-D-ARABINO-HEXITOL'>6HG</scene>, <scene name='pdbligand=6HT:1,5-ANHYDRO-2,3-DIDEOXY-2-(THYMIN-1-YL)-6-O-PHOSPHORYL-D-ARABINO-HEXITOL'>6HT</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
{{STRUCTURE_2bj6|  PDB=2bj6  |  SCENE=  }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2bj6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bj6 OCA], [https://pdbe.org/2bj6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2bj6 RCSB], [https://www.ebi.ac.uk/pdbsum/2bj6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2bj6 ProSAT]</span></td></tr>
</table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The crystal structure of a decameric HNA/RNA (HNA = 2',3'-dideoxy-1',5'-anhydro-d-arabinohexitol nucleic acid) hybrid with the RNA sequence 5'-GGCAUUACGG-3' is the first crystal structure of a hybrid duplex between a naturally occurring nucleic acid and a strand, which is fully modified to contain a six-membered ring instead of ribose. The presence of four duplex helices in the asymmetric unit allows for a detailed discussion of hydration, which revealed a tighter spinelike backbone hydration for the HNA- than for the RNA-strands. The reinforced backbone hydration is suggested to contribute significantly to the exceptional stability of HNA-containing duplexes and might be one of the causes for the evolutionary preference for ribose-derived nucleic acids.


===CRYSTAL STRUCTURE OF A DECAMERIC HNA-RNA HYBRID===
Reinforced HNA backbone hydration in the crystal structure of a decameric HNA/RNA hybrid.,Maier T, Przylas I, Strater N, Herdewijn P, Saenger W J Am Chem Soc. 2005 Mar 9;127(9):2937-43. PMID:15740130<ref>PMID:15740130</ref>


 
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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The line below this paragraph, {{ABSTRACT_PUBMED_15740130}}, adds the Publication Abstract to the page
<div class="pdbe-citations 2bj6" style="background-color:#fffaf0;"></div>
(as it appears on PubMed at http://www.pubmed.gov), where 15740130 is the PubMed ID number.
== References ==
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<references/>
{{ABSTRACT_PUBMED_15740130}}
__TOC__
 
</StructureSection>
==About this Structure==
[[Category: Homo sapiens]]
2BJ6 is a [[Single protein]] structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BJ6 OCA].
[[Category: Large Structures]]
 
[[Category: Herdewijn P]]
==Reference==
[[Category: Maier T]]
Reinforced HNA backbone hydration in the crystal structure of a decameric HNA/RNA hybrid., Maier T, Przylas I, Strater N, Herdewijn P, Saenger W, J Am Chem Soc. 2005 Mar 9;127(9):2937-43. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15740130 15740130]
[[Category: Przylas I]]
[[Category: Single protein]]
[[Category: Saenger W]]
[[Category: Herdewijn, P.]]
[[Category: Straeter N]]
[[Category: Maier, T.]]
[[Category: Przylas, I.]]
[[Category: Saenger, W.]]
[[Category: Straeter, N.]]
[[Category: Backbone modification]]
[[Category: Dna,rna,hna,hexitol nucleic acid,hybrid,duplex,modified nucleic acid,antisense]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 03:56:20 2008''

Latest revision as of 13:34, 30 August 2023

Crystal Structure of a decameric HNA-RNA hybrid

2bj6, resolution 2.60Å

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