3g80: Difference between revisions

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[[Image:3g80.jpg|left|200px]]


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==Nodamura virus protein b2, RNA-binding domain==
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<StructureSection load='3g80' size='340' side='right'caption='[[3g80]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)  
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[3g80]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Nodamura_virus Nodamura virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3G80 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3G80 FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3g80 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3g80 OCA], [https://pdbe.org/3g80 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3g80 RCSB], [https://www.ebi.ac.uk/pdbsum/3g80 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3g80 ProSAT]</span></td></tr>
{{STRUCTURE_3g80|  PDB=3g80  |  SCENE=  }}
</table>
== Function ==
[https://www.uniprot.org/uniprot/B2_NODAM B2_NODAM] Binds double-strand RNA (dsRNA) with high affinity. Suppresses the host RNA silencing-based antiviral response.<ref>PMID:19249868</ref>
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== Publication Abstract from PubMed ==
Protein B2 from Nodamura virus (NMV B2), a member of the Nodavirus family, acts as a suppressor of RNA interference (RNAi). The N-terminal domain of NMV B2, consisting of residues 1-79, recognizes double-stranded RNA (dsRNA). The 2.5 A crystal structure of the RNA-binding domain of NMV B2 shows a dimeric, helical bundle structure. The structure shows a conserved set of RNA-binding residues compared with flock house virus B2, despite limited sequence identity. The crystal packing places the RNA-binding residues along one face of symmetry-related molecules, suggesting a potential platform for recognition of dsRNA.


===Nodamura virus protein b2, RNA-binding domain===
Structure of the RNA-Binding Domain of Nodamura Virus Protein B2, a Suppressor of RNA Interference (dagger) , (double dagger).,Korber S, Shaik Syed Ali P, Chen JC Biochemistry. 2009 Mar 24;48(11):2307-9. PMID:19249868<ref>PMID:19249868</ref>


 
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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(as it appears on PubMed at http://www.pubmed.gov), where 19249868 is the PubMed ID number.
== References ==
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<references/>
{{ABSTRACT_PUBMED_19249868}}
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</StructureSection>
==About this Structure==
[[Category: Large Structures]]
3G80 is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Nodamura_virus Nodamura virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3G80 OCA].
 
==Reference==
<ref group="xtra">PMID:19249868</ref><references group="xtra"/>
[[Category: Nodamura virus]]
[[Category: Nodamura virus]]
[[Category: Ali, P Shaik Syed.]]
[[Category: Chen JC]]
[[Category: Chen, J C.]]
[[Category: Korber S]]
[[Category: Korber, S.]]
[[Category: Shaik Syed Ali P]]
[[Category: Rna interference]]
[[Category: Rna-binding]]
[[Category: Suppressor of rnai]]
[[Category: Viral protein]]
 
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