3hva: Difference between revisions

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[[Image:3hva.png|left|200px]]


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==Crystal structure of FimX GGDEF domain from Pseudomonas aeruginosa==
The line below this paragraph, containing "STRUCTURE_3hva", creates the "Structure Box" on the page.
<StructureSection load='3hva' size='340' side='right'caption='[[3hva]], [[Resolution|resolution]] 2.04&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[3hva]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_aeruginosa_PAO1 Pseudomonas aeruginosa PAO1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HVA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3HVA FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.042&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3hva FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hva OCA], [https://pdbe.org/3hva PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3hva RCSB], [https://www.ebi.ac.uk/pdbsum/3hva PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3hva ProSAT]</span></td></tr>
{{STRUCTURE_3hva|  PDB=3hva  |  SCENE=  }}
</table>
== Function ==
[https://www.uniprot.org/uniprot/Q9HUK6_PSEAE Q9HUK6_PSEAE]
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hv/3hva_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3hva ConSurf].
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Bacterial pathogenesis involves social behavior including biofilm formation and swarming, processes that are regulated by the bacterially unique second messenger cyclic di-GMP (c-di-GMP). Diguanylate cyclases containing GGDEF and phosphodiesterases containing EAL domains have been identified as the enzymes controlling cellular c-di-GMP levels, yet less is known regarding signal transmission and the targets of c-di-GMP. FimX, a protein from Pseudomonas aeruginosa that governs twitching motility, belongs to a large subfamily containing both GGDEF and EAL domains. Biochemical and structural analyses reveals its function as a high-affinity receptor for c-di-GMP. A model for full-length FimX was generated combining solution scattering data and crystal structures of the degenerate GGDEF and EAL domains. Although FimX forms a dimer in solution via the N-terminal domains, a crystallographic EAL domain dimer suggests modes for the regulation of FimX by c-di-GMP binding. The results provide the structural basis for c-di-GMP sensing via degenerate phosphodiesterases.


===Crystal structure of FimX GGDEF domain from Pseudomonas aeruginosa===
Structural analysis of the GGDEF-EAL domain-containing c-di-GMP receptor FimX.,Navarro MV, De N, Bae N, Wang Q, Sondermann H Structure. 2009 Aug 12;17(8):1104-16. PMID:19679088<ref>PMID:19679088</ref>


 
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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<div class="pdbe-citations 3hva" style="background-color:#fffaf0;"></div>
(as it appears on PubMed at http://www.pubmed.gov), where 19679088 is the PubMed ID number.
== References ==
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<references/>
{{ABSTRACT_PUBMED_19679088}}
__TOC__
 
</StructureSection>
==About this Structure==
[[Category: Large Structures]]
[[3hva]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Pseudomonas_aeruginosa_pao1 Pseudomonas aeruginosa pao1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HVA OCA].
[[Category: Pseudomonas aeruginosa PAO1]]
 
[[Category: Bae N]]
==Reference==
[[Category: De N]]
<ref group="xtra">PMID:019679088</ref><references group="xtra"/>
[[Category: Navarro MVAS]]
[[Category: Diguanylate kinase]]
[[Category: Sondermann H]]
[[Category: Pseudomonas aeruginosa pao1]]
[[Category: Bae, N.]]
[[Category: De, N.]]
[[Category: Navarro, M V.A S.]]
[[Category: Sondermann, H.]]
[[Category: Biofilm]]
[[Category: C-di-gmp]]
[[Category: Ggdef diguanylate cyclase]]
[[Category: Transferase]]
Retrieved from "https://proteopedia.org/3hva"