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==Crystal structure of a Rex-family repressor/DNA/NAD+ complex from Thermus aquaticus==
==Crystal structure of a Rex-family repressor/DNA/NAD+ complex from Thermus aquaticus==
<StructureSection load='3ikt' size='340' side='right' caption='[[3ikt]], [[Resolution|resolution]] 2.26&Aring;' scene=''>
<StructureSection load='3ikt' size='340' side='right'caption='[[3ikt]], [[Resolution|resolution]] 2.26&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3ikt]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Thet2 Thet2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IKT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3IKT FirstGlance]. <br>
<table><tr><td colspan='2'>[[3ikt]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermus_thermophilus_HB27 Thermus thermophilus HB27]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IKT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3IKT FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.26&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1xcb|1xcb]], [[3ikv|3ikv]], [[3il2|3il2]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">rex, TT_C1293 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=262724 THET2])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ikt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ikt OCA], [https://pdbe.org/3ikt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ikt RCSB], [https://www.ebi.ac.uk/pdbsum/3ikt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ikt ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ikt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ikt OCA], [http://pdbe.org/3ikt PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3ikt RCSB], [http://www.ebi.ac.uk/pdbsum/3ikt PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3ikt ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/REX_THET2 REX_THET2]] Modulates transcription in response to changes in cellular NADH/NAD(+) redox state (By similarity).  
[https://www.uniprot.org/uniprot/REX_THET2 REX_THET2] Modulates transcription in response to changes in cellular NADH/NAD(+) redox state (By similarity).
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Thet2]]
[[Category: Large Structures]]
[[Category: Kielkopf, C L]]
[[Category: Thermus thermophilus HB27]]
[[Category: McLaughlin, K J]]
[[Category: Kielkopf CL]]
[[Category: Cytoplasm]]
[[Category: McLaughlin KJ]]
[[Category: Dna binding protein]]
[[Category: Dna binding protein-dna complex]]
[[Category: Dna-binding]]
[[Category: Nad]]
[[Category: Nicotinamide adenine dinucleotide]]
[[Category: Redox-sensing]]
[[Category: Repressor]]
[[Category: Rex]]
[[Category: Rossmann fold]]
[[Category: Thermus aquaticus]]
[[Category: Transcription]]
[[Category: Transcription regulation]]
[[Category: Winged helix]]
Retrieved from "https://proteopedia.org/3ikt"