3lpv: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older edit
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,330,058 edits
No edit summary
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,330,058 edits
No edit summary
 
(6 intermediate revisions by the same user not shown)
Line 1: Line 1:
{{Seed}}
[[Image:3lpv.jpg|left|200px]]


<!--
==X-ray crystal structure of duplex DNA containing a cisplatin 1,2-d(GpG) intrastrand cross-link==
The line below this paragraph, containing "STRUCTURE_3lpv", creates the "Structure Box" on the page.
<StructureSection load='3lpv' size='340' side='right'caption='[[3lpv]], [[Resolution|resolution]] 1.77&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[3lpv]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LPV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3LPV FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.77&#8491;</td></tr>
-->
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CPT:CISPLATIN'>CPT</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
{{STRUCTURE_3lpv|  PDB=3lpv  |  SCENE=  }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3lpv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3lpv OCA], [https://pdbe.org/3lpv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3lpv RCSB], [https://www.ebi.ac.uk/pdbsum/3lpv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3lpv ProSAT]</span></td></tr>
</table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
We report the 1.77-A resolution X-ray crystal structure of a dodecamer DNA duplex with the sequence 5'-CCTCTGGTCTCC-3' that has been modified to contain a single engineered 1,2-cis-{Pt(NH(3))(2)}(2+)-d(GpG) cross-link, the major DNA adduct of cisplatin. These data represent a significant improvement in resolution over the previously published 2.6-A structure. The ammine ligands in this structure are clearly resolved, leading to improved visualization of the cross-link geometry with respect to both the platinum center and to the nucleobases, which adopt a higher energy conformation. Also better resolved are the deoxyribose sugar puckers, which allow us to re-examine the global structure of platinum-modified DNA. Another new feature of this model is the location of four octahedral [Mg(H(2)O)(6)](2+) ions associated with bases in the DNA major groove and the identification of 124 ordered water molecules that participate in hydrogen-bonding interactions with either the nucleic acid or the diammineplatinum(II) moiety.


===X-ray crystal structure of duplex DNA containing a cisplatin 1,2-d(GpG) intrastrand cross-link===
Structure of duplex DNA containing the cisplatin 1,2-{Pt(NH3)2}2+-d(GpG) cross-link at 1.77 A resolution.,Todd RC, Lippard SJ J Inorg Biochem. 2010 Sep;104(9):902-8. Epub 2010 Apr 18. PMID:20541266<ref>PMID:20541266</ref>


 
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
<!--
</div>
The line below this paragraph, {{ABSTRACT_PUBMED_20541266}}, adds the Publication Abstract to the page
<div class="pdbe-citations 3lpv" style="background-color:#fffaf0;"></div>
(as it appears on PubMed at http://www.pubmed.gov), where 20541266 is the PubMed ID number.
== References ==
-->
<references/>
{{ABSTRACT_PUBMED_20541266}}
__TOC__
 
</StructureSection>
==About this Structure==
[[Category: Large Structures]]
3LPV is a 4 chains structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LPV OCA].
[[Category: Lippard SJ]]
 
[[Category: Todd RC]]
==Reference==
<ref group="xtra">PMID:20541266</ref><references group="xtra"/>
[[Category: Lippard, S J.]]
[[Category: Todd, R C.]]
[[Category: Cisplatin]]
[[Category: Dna]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Aug 11 23:56:05 2010''

Latest revision as of 08:42, 6 September 2023

X-ray crystal structure of duplex DNA containing a cisplatin 1,2-d(GpG) intrastrand cross-link

3lpv, resolution 1.77Å

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "https://proteopedia.org/index.php?title=3lpv&oldid=3866738"