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==Crystal structure of Rv3671c from M. tuberculosis H37Rv, Ser343Ala mutant, inactive form==
==Crystal structure of Rv3671c from M. tuberculosis H37Rv, Ser343Ala mutant, inactive form==
<StructureSection load='3lt3' size='340' side='right' caption='[[3lt3]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
<StructureSection load='3lt3' size='340' side='right'caption='[[3lt3]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3lt3]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Myctu Myctu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LT3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3LT3 FirstGlance]. <br>
<table><tr><td colspan='2'>[[3lt3]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LT3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3LT3 FirstGlance]. <br>
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3k6y|3k6y]], [[3k6z|3k6z]]</td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">MT3772, Rv3671c ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83332 MYCTU])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3lt3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3lt3 OCA], [https://pdbe.org/3lt3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3lt3 RCSB], [https://www.ebi.ac.uk/pdbsum/3lt3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3lt3 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3lt3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3lt3 OCA], [http://pdbe.org/3lt3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3lt3 RCSB], [http://www.ebi.ac.uk/pdbsum/3lt3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3lt3 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/Y3671_MYCTU Y3671_MYCTU]] Required for M.tuberculosis resistance to oxidative stress in addition to its role in resistance to acid, which is essential for virulence. It protects M.tuberculosis against phagolysosomal concentrations of acid and maintains its intrabacterial pH when phagocytosed by IFN-gamma-activated macrophages.<ref>PMID:18641659</ref> <ref>PMID:20947023</ref>
[https://www.uniprot.org/uniprot/Y3671_MYCTU Y3671_MYCTU] Required for M.tuberculosis resistance to oxidative stress in addition to its role in resistance to acid, which is essential for virulence. It protects M.tuberculosis against phagolysosomal concentrations of acid and maintains its intrabacterial pH when phagocytosed by IFN-gamma-activated macrophages.<ref>PMID:18641659</ref> <ref>PMID:20947023</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Myctu]]
[[Category: Large Structures]]
[[Category: Biswas, T]]
[[Category: Mycobacterium tuberculosis H37Rv]]
[[Category: Ehrt, S]]
[[Category: Biswas T]]
[[Category: Small, J]]
[[Category: Ehrt S]]
[[Category: Tsodikov, O V]]
[[Category: Small J]]
[[Category: Vandal, O]]
[[Category: Tsodikov OV]]
[[Category: H37rv]]
[[Category: Vandal O]]
[[Category: Htra]]
[[Category: Hydrolase]]
[[Category: Protease]]
[[Category: Serine protease]]
Retrieved from "https://proteopedia.org/3lt3"