3n95: Difference between revisions

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~~'''Unreleased structure'''~~

~~The entry 3n95 is ON HOLD~~

==Crystal structure of human CRFR2 alpha extracellular domain in complex with Urocortin 2==

~~Authors: Pal, Kuntal, Swaminathan, K., Pioszak, Augen A., Xu, H. E.~~

== Structural highlights ==

<table><tr><td colspan='2'>[[3n95]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3N95 OCA]. For a guided tour on the structure components use [https://proteopedia.org/fgij/fg.htm?mol=3N95 FirstGlance].

~~Description:~~ Crystal structure of human CRFR2 alpha extracellular domain in complex with Urocortin 2

</td></tr><tr id='method'><td class="sblockLbl">[[Empirical_models|Method:]]</td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.72Å</td></tr>

<tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GLC:ALPHA-D-GLUCOSE'>GLC</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene>, <scene name='pdbligand=PRD_900001:alpha-maltose'>PRD_900001</scene></td></tr>

''~~Page seeded by~~ [http://oca.weizmann.ac.il/oca OCA ] on ~~Thu Jun 10 10~~:58:~~50 2010~~''

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[https://proteopedia.org/fgij/fg.htm?mol=3n95 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3n95 OCA], [https://pdbe.org/3n95 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3n95 RCSB], [https://www.ebi.ac.uk/pdbsum/3n95 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3n95 ProSAT]</td></tr>

</table>

== Function ==

[https://www.uniprot.org/uniprot/MALE_ECOLI MALE_ECOLI] Involved in the high-affinity maltose membrane transport system MalEFGK. Initial receptor for the active transport of and chemotaxis toward maltooligosaccharides.[https://www.uniprot.org/uniprot/CRFR2_HUMAN CRFR2_HUMAN] G-protein coupled receptor for CRH (corticotropin-releasing factor), UCN (urocortin), UCN2 and UCN3. Has high affinity for UCN. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and down-stream effectors, such as adenylate cyclase. Promotes the activation of adenylate cyclase, leading to increased intracellular cAMP levels.

__TOC__

</StructureSection>

[[Category: Homo sapiens]]

[[Category: Large Structures]]

[[Category: Pal K]]

[[Category: Pioszak AA]]

[[Category: Swaminathan K]]

[[Category: Xu HE]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 3n95 is ON HOLD
+==Crystal structure of human CRFR2 alpha extracellular domain in complex with Urocortin 2==
+<StructureSection load='3n95' size='340' side='right'caption='[[3n95]], [[Resolution|resolution]] 2.72&Aring;' scene=''>
-Authors: Pal, Kuntal, Swaminathan, K., Pioszak, Augen A., Xu, H. E.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[3n95]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3N95 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3N95 FirstGlance]. <br>
-Description: Crystal structure of human CRFR2 alpha extracellular domain in complex with Urocortin 2
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.72&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GLC:ALPHA-D-GLUCOSE'>GLC</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene>, <scene name='pdbligand=PRD_900001:alpha-maltose'>PRD_900001</scene></td></tr>
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jun 10 10:58:50 2010''
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3n95 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3n95 OCA], [https://pdbe.org/3n95 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3n95 RCSB], [https://www.ebi.ac.uk/pdbsum/3n95 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3n95 ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/MALE_ECOLI MALE_ECOLI] Involved in the high-affinity maltose membrane transport system MalEFGK. Initial receptor for the active transport of and chemotaxis toward maltooligosaccharides.[https://www.uniprot.org/uniprot/CRFR2_HUMAN CRFR2_HUMAN] G-protein coupled receptor for CRH (corticotropin-releasing factor), UCN (urocortin), UCN2 and UCN3. Has high affinity for UCN. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and down-stream effectors, such as adenylate cyclase. Promotes the activation of adenylate cyclase, leading to increased intracellular cAMP levels.
+__TOC__
+</StructureSection>
+[[Category: Homo sapiens]]
+[[Category: Large Structures]]
+[[Category: Pal K]]
+[[Category: Pioszak AA]]
+[[Category: Swaminathan K]]
+[[Category: Xu HE]]