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==Structure of the structure of the H13A mutant of Ykr043C in complex with sedoheptulose-1,7-bisphosphate==
==Structure of the structure of the H13A mutant of Ykr043C in complex with sedoheptulose-1,7-bisphosphate==
<StructureSection load='3oi7' size='340' side='right' caption='[[3oi7]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
<StructureSection load='3oi7' size='340' side='right'caption='[[3oi7]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3oi7]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OI7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3OI7 FirstGlance]. <br>
<table><tr><td colspan='2'>[[3oi7]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OI7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3OI7 FirstGlance]. <br>
</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=OI7:1,7-DI-O-PHOSPHONO-BETA-D-ALTRO-HEPT-2-ULOFURANOSE'>OI7</scene><br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
<tr><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=OI7:1,7-DI-O-PHOSPHONO-BETA-D-ALTRO-HEPT-2-ULOFURANOSE'>OI7</scene></td></tr>
<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3f3k|3f3k]], [[3lg2|3lg2]], [[3ll4|3ll4]]</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3oi7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3oi7 OCA], [https://pdbe.org/3oi7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3oi7 RCSB], [https://www.ebi.ac.uk/pdbsum/3oi7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3oi7 ProSAT]</span></td></tr>
<tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">YKR043C ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 Saccharomyces cerevisiae])</td></tr>
</table>
<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Fructose-bisphosphatase Fructose-bisphosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.11 3.1.3.11] </span></td></tr>
== Function ==
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3oi7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3oi7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3oi7 RCSB], [http://www.ebi.ac.uk/pdbsum/3oi7 PDBsum]</span></td></tr>
[https://www.uniprot.org/uniprot/SHB17_YEAST SHB17_YEAST] Sedoheptulose 1,7-bisphosphatase involved in riboneogenesis. Dephosphorylates sedoheptulose 1,7-bisphosphate (SBP), which is converted via the non-oxidative pentose phosphate pathway to ribose-5-phosphate. Has a fructose 1,6-bisphosphatase activity in vitro, but this is probably not biologically relevant, since deletion does not affect fructose 1,6-biphosphate (FBP) levels.<ref>PMID:21663798</ref>  
<table>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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Riboneogenesis in yeast.,Clasquin MF, Melamud E, Singer A, Gooding JR, Xu X, Dong A, Cui H, Campagna SR, Savchenko A, Yakunin AF, Rabinowitz JD, Caudy AA Cell. 2011 Jun 10;145(6):969-80. PMID:21663798<ref>PMID:21663798</ref>
Riboneogenesis in yeast.,Clasquin MF, Melamud E, Singer A, Gooding JR, Xu X, Dong A, Cui H, Campagna SR, Savchenko A, Yakunin AF, Rabinowitz JD, Caudy AA Cell. 2011 Jun 10;145(6):969-80. PMID:21663798<ref>PMID:21663798</ref>


From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
<div class="pdbe-citations 3oi7" style="background-color:#fffaf0;"></div>
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Fructose-bisphosphatase]]
[[Category: Large Structures]]
[[Category: Saccharomyces cerevisiae]]
[[Category: Saccharomyces cerevisiae]]
[[Category: Caudy, A A.]]
[[Category: Caudy AA]]
[[Category: Clasquin, M F.]]
[[Category: Clasquin MF]]
[[Category: Cui, H.]]
[[Category: Cui H]]
[[Category: Dong, A.]]
[[Category: Dong A]]
[[Category: Edwards, A M.]]
[[Category: Edwards AM]]
[[Category: Joachimiak, A.]]
[[Category: Joachimiak A]]
[[Category: MCSG, Midwest Center for Structural Genomics.]]
[[Category: Savchenko A]]
[[Category: Savchenko, A.]]
[[Category: Singer AU]]
[[Category: Singer, A U.]]
[[Category: Xu X]]
[[Category: Xu, X.]]
[[Category: Yakunin AF]]
[[Category: Yakunin, A F.]]
[[Category: 7-bisphosphatase]]
[[Category: Alpha-beta]]
[[Category: Beta-furanose]]
[[Category: Hydrolase]]
[[Category: Mcsg]]
[[Category: Midwest center for structural genomic]]
[[Category: Phosphatase]]
[[Category: Protein structure initiative]]
[[Category: Psi-2]]
[[Category: Sedoheptulose-1]]
[[Category: Structural genomic]]
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