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==X-ray crystal structure of Archaeoglobus fulgidus Rio1 bound to (2E)-N-benzyl-2-cyano-3-(pyridine-4-yl)acrylamide (WP1086)==
==X-ray crystal structure of Archaeoglobus fulgidus Rio1 bound to (2E)-N-benzyl-2-cyano-3-(pyridine-4-yl)acrylamide (WP1086)==
<StructureSection load='4jin' size='340' side='right' caption='[[4jin]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
<StructureSection load='4jin' size='340' side='right'caption='[[4jin]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4jin]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Arcfu Arcfu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JIN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4JIN FirstGlance]. <br>
<table><tr><td colspan='2'>[[4jin]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Archaeoglobus_fulgidus_DSM_4304 Archaeoglobus fulgidus DSM 4304]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JIN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4JIN FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1L7:(2E)-N-BENZYL-2-CYANO-3-(PYRIDIN-4-YL)PROP-2-ENAMIDE'>1L7</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.095&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1ztf|1ztf]], [[1zp9|1zp9]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1L7:(2E)-N-BENZYL-2-CYANO-3-(PYRIDIN-4-YL)PROP-2-ENAMIDE'>1L7</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">AF_1804, rio1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=224325 ARCFU])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4jin FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jin OCA], [https://pdbe.org/4jin PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4jin RCSB], [https://www.ebi.ac.uk/pdbsum/4jin PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4jin ProSAT]</span></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4jin FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jin OCA], [http://pdbe.org/4jin PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4jin RCSB], [http://www.ebi.ac.uk/pdbsum/4jin PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4jin ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/RIO1_ARCFU RIO1_ARCFU]] Autophosphorylation of the rio1 protein is not necessary for maintenance of kinase activity. Prefers ATP over GTP. The yeast ortholog is involved in ribosome biogenesis.  
[https://www.uniprot.org/uniprot/RIO1_ARCFU RIO1_ARCFU] Autophosphorylation of the rio1 protein is not necessary for maintenance of kinase activity. Prefers ATP over GTP. The yeast ortholog is involved in ribosome biogenesis.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Arcfu]]
[[Category: Archaeoglobus fulgidus DSM 4304]]
[[Category: Non-specific serine/threonine protein kinase]]
[[Category: Large Structures]]
[[Category: Fokt, I]]
[[Category: Fokt I]]
[[Category: Grzelak, K]]
[[Category: Grzelak K]]
[[Category: Kiburu, I]]
[[Category: Kiburu I]]
[[Category: Kierdaszuk, B]]
[[Category: Kierdaszuk B]]
[[Category: Kowa, K]]
[[Category: Kowa K]]
[[Category: Krawiec, K]]
[[Category: Krawiec K]]
[[Category: LaRonde-LeBlanc, N]]
[[Category: LaRonde-LeBlanc N]]
[[Category: Lesyng, B]]
[[Category: Lesyng B]]
[[Category: Mielecki, M]]
[[Category: Mielecki M]]
[[Category: Piotr, S]]
[[Category: Piotr S]]
[[Category: Priebe, W]]
[[Category: Priebe W]]
[[Category: Szeja, W]]
[[Category: Szeja W]]
[[Category: Szymanski, S]]
[[Category: Szymanski S]]
[[Category: Wlodzimierz, Z]]
[[Category: Wlodzimierz Z]]
[[Category: Autophosphorylation]]
[[Category: Pre-40]]
[[Category: Protein kinase]]
[[Category: Ribosome biogenesis]]
[[Category: Transferase-transferase inhibitor complex]]
Retrieved from "https://proteopedia.org/4jin"