4m7l: Difference between revisions

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==Crystal structure of the complex between human tissue factor extracellular domain and antibody 10H10 FAB fragment==
==Crystal structure of the complex between human tissue factor extracellular domain and antibody 10H10 FAB fragment==
<StructureSection load='4m7l' size='340' side='right' caption='[[4m7l]], [[Resolution|resolution]] 3.40&Aring;' scene=''>
<StructureSection load='4m7l' size='340' side='right'caption='[[4m7l]], [[Resolution|resolution]] 3.40&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4m7l]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4M7L OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4M7L FirstGlance]. <br>
<table><tr><td colspan='2'>[[4m7l]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4M7L OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4M7L FirstGlance]. <br>
</td></tr><tr><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=PCA:PYROGLUTAMIC+ACID'>PCA</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.4&#8491;</td></tr>
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4m7l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4m7l OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4m7l RCSB], [http://www.ebi.ac.uk/pdbsum/4m7l PDBsum]</span></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PCA:PYROGLUTAMIC+ACID'>PCA</scene></td></tr>
<table>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4m7l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4m7l OCA], [https://pdbe.org/4m7l PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4m7l RCSB], [https://www.ebi.ac.uk/pdbsum/4m7l PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4m7l ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/TF_HUMAN TF_HUMAN] Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited protolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade.<ref>PMID:12652293</ref>
 
==See Also==
*[[Tissue factor|Tissue factor]]
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Gilliland, G L.]]
[[Category: Homo sapiens]]
[[Category: Malia, T.]]
[[Category: Large Structures]]
[[Category: Obmolova, G.]]
[[Category: Mus musculus]]
[[Category: Teplyakov, A.]]
[[Category: Gilliland GL]]
[[Category: Antibody]]
[[Category: Malia T]]
[[Category: Blood clotting-immune system complex]]
[[Category: Obmolova G]]
[[Category: Teplyakov A]]
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