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==Crystal structure of an isatin hydrolase bound to product analogue thioisatinate==
==Crystal structure of an isatin hydrolase bound to product analogue thioisatinate==
<StructureSection load='4m8d' size='340' side='right' caption='[[4m8d]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
<StructureSection load='4m8d' size='340' side='right'caption='[[4m8d]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4m8d]] is a 12 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4M8D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4M8D FirstGlance]. <br>
<table><tr><td colspan='2'>[[4m8d]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Roseibium_aggregatum_IAM_12614 Roseibium aggregatum IAM 12614]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4M8D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4M8D FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=23J:OXO(2-SULFANYLPHENYL)ACETIC+ACID'>23J</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4j0n|4j0n]], [[4jb5|4jb5]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=23J:OXO(2-SULFANYLPHENYL)ACETIC+ACID'>23J</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4m8d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4m8d OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4m8d RCSB], [http://www.ebi.ac.uk/pdbsum/4m8d PDBsum]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4m8d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4m8d OCA], [https://pdbe.org/4m8d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4m8d RCSB], [https://www.ebi.ac.uk/pdbsum/4m8d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4m8d ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/ISAHY_ROSAI ISAHY_ROSAI] Involved in the degradation of the plant hormone indole-3-acetic acid (IAA). Catalyzes the hydrolysis of the cyclic amide bond (lactam) of isatin (1H-indole-2,3-dione) to yield isatinate (2-(2-aminophenyl)-2-oxoacetate).<ref>PMID:24917679</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
<div class="pdbe-citations 4m8d" style="background-color:#fffaf0;"></div>
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Bjerregaard-Andersen, K.]]
[[Category: Large Structures]]
[[Category: Etzerodt, M.]]
[[Category: Roseibium aggregatum IAM 12614]]
[[Category: Jensen, J K.]]
[[Category: Bjerregaard-Andersen K]]
[[Category: Jochimsen, B.]]
[[Category: Etzerodt M]]
[[Category: Morth, J P.]]
[[Category: Jensen JK]]
[[Category: Sommer, T.]]
[[Category: Jochimsen B]]
[[Category: Hydrolase]]
[[Category: Morth JP]]
[[Category: Isatin hydrolysis]]
[[Category: Sommer T]]
Retrieved from "https://proteopedia.org/4m8d"