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==Cubic crystal form of PIR1 dual specificity phosphatase core==
==Cubic crystal form of PIR1 dual specificity phosphatase core==
<StructureSection load='4mbb' size='340' side='right' caption='[[4mbb]], [[Resolution|resolution]] 1.85&Aring;' scene=''>
<StructureSection load='4mbb' size='340' side='right'caption='[[4mbb]], [[Resolution|resolution]] 1.85&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4mbb]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MBB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4MBB FirstGlance]. <br>
<table><tr><td colspan='2'>[[4mbb]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MBB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4MBB FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.849&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3cm3|3cm3]], [[1vhr|1vhr]], [[1yn9|1yn9]], [[1i9s|1i9s]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">DUSP11, PIR1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4mbb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mbb OCA], [https://pdbe.org/4mbb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4mbb RCSB], [https://www.ebi.ac.uk/pdbsum/4mbb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4mbb ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4mbb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mbb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4mbb RCSB], [http://www.ebi.ac.uk/pdbsum/4mbb PDBsum]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/DUS11_HUMAN DUS11_HUMAN]] Possesses RNA 5'-triphosphatase and diphosphatase activities, but displays a poor protein-tyrosine phosphatase activity. Binds to RNA. May participate in nuclear mRNA metabolism.<ref>PMID:9685386</ref>
[https://www.uniprot.org/uniprot/DUS11_HUMAN DUS11_HUMAN] Possesses RNA 5'-triphosphatase and diphosphatase activities, but displays a poor protein-tyrosine phosphatase activity. Binds to RNA. May participate in nuclear mRNA metabolism.<ref>PMID:9685386</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
<div class="pdbe-citations 4mbb" style="background-color:#fffaf0;"></div>
==See Also==
*[[Dual specificity phosphatase 3D structures|Dual specificity phosphatase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Cingolani, G]]
[[Category: Large Structures]]
[[Category: Lokareddy, R K]]
[[Category: Cingolani G]]
[[Category: Sankhala, R S]]
[[Category: Lokareddy RK]]
[[Category: Atypical dual specificity phosphatase]]
[[Category: Sankhala RS]]
[[Category: Deep catalytic cleft]]
[[Category: Dephosphorylation]]
[[Category: Dual specificity phosphatase]]
[[Category: Helical hairpin]]
[[Category: Hydrolase]]
[[Category: Nucleus]]
[[Category: Pir1-core]]
[[Category: Ptp-loop]]
[[Category: Rna phosphatase]]
[[Category: Rna splicing]]
[[Category: Rna-rnp complex-1]]
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