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==Structure of active human M2 muscarinic acetylcholine receptor bound to the agonist iperoxo==
==Structure of active human M2 muscarinic acetylcholine receptor bound to the agonist iperoxo==
<StructureSection load='4mqs' size='340' side='right' caption='[[4mqs]], [[Resolution|resolution]] 3.50&Aring;' scene=''>
<StructureSection load='4mqs' size='340' side='right'caption='[[4mqs]], [[Resolution|resolution]] 3.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4mqs]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Camelus_glama Camelus glama] and [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MQS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4MQS FirstGlance]. <br>
<table><tr><td colspan='2'>[[4mqs]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Lama_glama Lama glama]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MQS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4MQS FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=IXO:4-(4,5-DIHYDRO-1,2-OXAZOL-3-YLOXY)-N,N,N-TRIMETHYLBUT-2-YN-1-AMINIUM'>IXO</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.5&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3uon|3uon]], [[4mqt|4mqt]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IXO:4-(4,5-DIHYDRO-1,2-OXAZOL-3-YLOXY)-N,N,N-TRIMETHYLBUT-2-YN-1-AMINIUM'>IXO</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CHRM2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4mqs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mqs OCA], [https://pdbe.org/4mqs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4mqs RCSB], [https://www.ebi.ac.uk/pdbsum/4mqs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4mqs ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4mqs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mqs OCA], [http://pdbe.org/4mqs PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4mqs RCSB], [http://www.ebi.ac.uk/pdbsum/4mqs PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4mqs ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
[[http://www.uniprot.org/uniprot/ACM2_HUMAN ACM2_HUMAN]] Disease susceptibility is associated with variations affecting the gene represented in this entry.  
[https://www.uniprot.org/uniprot/ACM2_HUMAN ACM2_HUMAN] Disease susceptibility is associated with variations affecting the gene represented in this entry.
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/ACM2_HUMAN ACM2_HUMAN]] The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is adenylate cyclase inhibition.  
[https://www.uniprot.org/uniprot/ACM2_HUMAN ACM2_HUMAN] The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is adenylate cyclase inhibition.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 4mqs" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 4mqs" style="background-color:#fffaf0;"></div>
==See Also==
*[[Muscarinic acetylcholine receptor|Muscarinic acetylcholine receptor]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Camelus glama]]
[[Category: Homo sapiens]]
[[Category: Human]]
[[Category: Lama glama]]
[[Category: Christopoulos, A]]
[[Category: Large Structures]]
[[Category: Eitel, K]]
[[Category: Christopoulos A]]
[[Category: Felder, C C]]
[[Category: Eitel K]]
[[Category: Garcia, K C]]
[[Category: Felder CC]]
[[Category: Gmeiner, P]]
[[Category: Garcia KC]]
[[Category: Hu, J]]
[[Category: Gmeiner P]]
[[Category: Hu, K]]
[[Category: Hu J]]
[[Category: Huebner, H]]
[[Category: Hu K]]
[[Category: Kobilka, B K]]
[[Category: Huebner H]]
[[Category: Kruse, A C]]
[[Category: Kobilka BK]]
[[Category: Manglik, A]]
[[Category: Kruse AC]]
[[Category: Pardon, E]]
[[Category: Manglik A]]
[[Category: Ring, A M]]
[[Category: Pardon E]]
[[Category: Sexton, P M]]
[[Category: Ring AM]]
[[Category: Steyaert, J]]
[[Category: Sexton PM]]
[[Category: Valant, C]]
[[Category: Steyaert J]]
[[Category: Weis, W I]]
[[Category: Valant C]]
[[Category: Wess, J]]
[[Category: Weis WI]]
[[Category: G protein-coupled receptor]]
[[Category: Wess J]]
[[Category: Muscarinic acetylcholine receptor]]
[[Category: Signaling protein]]
Retrieved from "https://proteopedia.org/4mqs"