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==Carbamate kinase from Giardia lamblia thiocarbamoylated by disulfiram on Cys242==
==Carbamate kinase from Giardia lamblia thiocarbamoylated by disulfiram on Cys242==
<StructureSection load='4olc' size='340' side='right' caption='[[4olc]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
<StructureSection load='4olc' size='340' side='right'caption='[[4olc]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4olc]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Giaic Giaic]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OLC OCA]. <br>
<table><tr><td colspan='2'>[[4olc]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Giardia_lamblia_ATCC_50803 Giardia lamblia ATCC 50803]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OLC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4OLC FirstGlance]. <br>
</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene>, <scene name='pdbligand=DCD:DIETHYLCARBAMODITHIOIC+ACID'>DCD</scene><br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3kzf|3kzf]], [[4jz7|4jz7]], [[4jz8|4jz8]], [[4jz9|4jz9]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene>, <scene name='pdbligand=DCD:DIETHYLCARBAMODITHIOIC+ACID'>DCD</scene></td></tr>
<tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">GL50803_16453 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=184922 GIAIC])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4olc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4olc OCA], [https://pdbe.org/4olc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4olc RCSB], [https://www.ebi.ac.uk/pdbsum/4olc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4olc ProSAT]</span></td></tr>
<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span></td></tr>
</table>
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4olc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4olc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4olc RCSB], [http://www.ebi.ac.uk/pdbsum/4olc PDBsum]</span></td></tr>
== Function ==
<table>
[https://www.uniprot.org/uniprot/A8BB85_GIAIC A8BB85_GIAIC]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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Structural Basis for Inactivation of Giardia lamblia Carbamate Kinase by Disulfiram.,Galkin A, Kulakova L, Lim K, Chen CZ, Zheng W, Turko IV, Herzberg O J Biol Chem. 2014 Feb 20. PMID:24558036<ref>PMID:24558036</ref>
Structural Basis for Inactivation of Giardia lamblia Carbamate Kinase by Disulfiram.,Galkin A, Kulakova L, Lim K, Chen CZ, Zheng W, Turko IV, Herzberg O J Biol Chem. 2014 Feb 20. PMID:24558036<ref>PMID:24558036</ref>


From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
<div class="pdbe-citations 4olc" style="background-color:#fffaf0;"></div>
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Carbamate kinase]]
[[Category: Giardia lamblia ATCC 50803]]
[[Category: Giaic]]
[[Category: Large Structures]]
[[Category: Herzberg, O.]]
[[Category: Herzberg O]]
[[Category: Lim, K.]]
[[Category: Lim K]]
[[Category: Adp]]
[[Category: Carbamate]]
[[Category: Carbamoyl phosphate]]
[[Category: Mg2+]]
[[Category: Transferase]]
Retrieved from "https://proteopedia.org/4olc"