4pid: Difference between revisions

<StructureSection load='4pid' size='340' side='right'caption='[[4pid]], [[Resolution|resolution]] 1.59&Aring;' scene=''>

<table><tr><td colspan='2'>[[4pid]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_adenovirus_2 Human adenovirus 2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PID OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4PID FirstGlance]. <br>

</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.59&#8491;</td></tr>

<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2UQ:N-BENZYL-2-[(Z)-IMINOMETHYL]PYRIMIDINE-5-CARBOXAMIDE'>2UQ</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4pid FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pid OCA], [https://pdbe.org/4pid PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4pid RCSB], [https://www.ebi.ac.uk/pdbsum/4pid PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4pid ProSAT]</span></td></tr>

</table>

[https://www.uniprot.org/uniprot/PRO_ADE02 PRO_ADE02] Cleaves viral precursor proteins (pTP, pIIIa, pVI, pVII, pVIII, and pX) inside newly assembled particles giving rise to mature virions. Protease complexed to its cofactor slides along the viral DNA to specifically locate and cleave the viral precursors. Mature virions have a weakened organization compared to the unmature virions, thereby facilitating subsequent uncoating. Without maturation, the particle lacks infectivity and is unable to uncoat. Late in adenovirus infection, in the cytoplasm, may participate in the cytoskeleton destruction. Cleaves host cells cytoskeletal keratins K7 and K18.<ref>PMID:22791715</ref>  

[[Category: Human adenovirus 2]]

[[Category: Large Structures]]

[[Category: Altmann E]]

[[Category: Bernardi A]]

[[Category: Combrink K]]

[[Category: Ellis D]]

[[Category: Erbel P]]

[[Category: Grosche P]]

[[Category: Hughes N]]

[[Category: Jarousse N]]

[[Category: Mac Sweeney A]]

[[Category: Melkko S]]

[[Category: Ramage P]]

[[Category: Sirockin F]]