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==Crystal structure of murine IRE1 in complex with OICR573 inhibitor==
==Crystal structure of murine IRE1 in complex with OICR573 inhibitor==
<StructureSection load='4pl5' size='340' side='right' caption='[[4pl5]], [[Resolution|resolution]] 3.40&Aring;' scene=''>
<StructureSection load='4pl5' size='340' side='right'caption='[[4pl5]], [[Resolution|resolution]] 3.40&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4pl5]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PL5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4PL5 FirstGlance]. <br>
<table><tr><td colspan='2'>[[4pl5]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PL5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4PL5 FirstGlance]. <br>
</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=31L:3-METHOXY-5-METHYL-4-(MORPHOLIN-4-YL)BIPHENYL-4-OL'>31L</scene>, <scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PEU:2,5,8,11,14,17,20,23,26,29,32,35,38,41,44,47,50,53,56,59,62,65,68,71,74,77,80-HEPTACOSAOXADOOCTACONTAN-82-OL'>PEU</scene><br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.4&#8491;</td></tr>
<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4pl3|4pl3]], [[4pl4|4pl4]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=31L:3-METHOXY-5-METHYL-4-(MORPHOLIN-4-YL)BIPHENYL-4-OL'>31L</scene>, <scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PEU:2,5,8,11,14,17,20,23,26,29,32,35,38,41,44,47,50,53,56,59,62,65,68,71,74,77,80-HEPTACOSAOXADOOCTACONTAN-82-OL'>PEU</scene></td></tr>
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4pl5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pl5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4pl5 RCSB], [http://www.ebi.ac.uk/pdbsum/4pl5 PDBsum]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4pl5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pl5 OCA], [https://pdbe.org/4pl5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4pl5 RCSB], [https://www.ebi.ac.uk/pdbsum/4pl5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4pl5 ProSAT]</span></td></tr>
<table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/ERN1_MOUSE ERN1_MOUSE] Senses unfolded proteins in the lumen of the endoplasmic reticulum via its N-terminal domain which leads to enzyme auto-activation. The active endoribonuclease domain splices XBP1 mRNA to generate a new C-terminus, converting it into a potent unfolded-protein response transcriptional activator and triggering growth arrest and apoptosis.<ref>PMID:11850408</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
<div class="pdbe-citations 4pl5" style="background-color:#fffaf0;"></div>
==See Also==
*[[Ire1|Ire1]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Al-awar, R.]]
[[Category: Large Structures]]
[[Category: Chiovitti, D.]]
[[Category: Mus musculus]]
[[Category: Duffy, N.]]
[[Category: Al-awar R]]
[[Category: Patterson, J B.]]
[[Category: Chiovitti D]]
[[Category: Sanches, M.]]
[[Category: Duffy N]]
[[Category: Sicheri, F.]]
[[Category: Patterson JB]]
[[Category: Talukdar, M.]]
[[Category: Sanches M]]
[[Category: Thevakumaran, N.]]
[[Category: Sicheri F]]
[[Category: Endoribonuclease]]
[[Category: Talukdar M]]
[[Category: Inhibitor complex]]
[[Category: Thevakumaran N]]
[[Category: Schiff base]]
[[Category: Unfolded protein response]]
Retrieved from "https://proteopedia.org/4pl5"