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==Structure of Mycobacterium tuberculosis NadD in complex with NADP, P21212==
==Structure of Mycobacterium tuberculosis NadD in complex with NADP, P21212==
<StructureSection load='4ybr' size='340' side='right' caption='[[4ybr]], [[Resolution|resolution]] 1.65&Aring;' scene=''>
<StructureSection load='4ybr' size='340' side='right'caption='[[4ybr]], [[Resolution|resolution]] 1.65&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4ybr]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Myctu Myctu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YBR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4YBR FirstGlance]. <br>
<table><tr><td colspan='2'>[[4ybr]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YBR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4YBR FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.65&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4s1o|4s1o]], [[4x0e|4x0e]], [[4rpi|4rpi]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">nadD, Rv2421c, MTCY428.26 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83332 MYCTU])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ybr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ybr OCA], [https://pdbe.org/4ybr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ybr RCSB], [https://www.ebi.ac.uk/pdbsum/4ybr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ybr ProSAT]</span></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Nicotinate-nucleotide_adenylyltransferase Nicotinate-nucleotide adenylyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.18 2.7.7.18] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ybr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ybr OCA], [http://pdbe.org/4ybr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4ybr RCSB], [http://www.ebi.ac.uk/pdbsum/4ybr PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4ybr ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/NADD_MYCTU NADD_MYCTU]] Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).  
[https://www.uniprot.org/uniprot/NADD_MYCTU NADD_MYCTU] Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Myctu]]
[[Category: Large Structures]]
[[Category: Nicotinate-nucleotide adenylyltransferase]]
[[Category: Mycobacterium tuberculosis H37Rv]]
[[Category: Korotkov, K V]]
[[Category: Korotkov KV]]
[[Category: Rossmann fold]]
[[Category: Transferase]]

Latest revision as of 07:56, 27 September 2023

Structure of Mycobacterium tuberculosis NadD in complex with NADP, P21212

4ybr, resolution 1.65Å

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