5cef

Cystal structure of aspartate semialdehyde dehydrogenase from Cryptococcus neoformans

spinqualitylabelsall models 5cef, resolution 2.60Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 5cef is a 4 chain structure with sequence from Cryptococcus neoformans var. neoformans JEC21. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 2.6Å Ligands: EDO Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function Q5KPK7_CRYNJ Publication Abstract from PubMed Aspartate semialdehyde dehydrogenase (ASADH) functions at a critical junction in the aspartate-biosynthetic pathway and represents a valid target for antimicrobial drug design. This enzyme catalyzes the NADPH-dependent reductive dephosphorylation of beta-aspartyl phosphate to produce the key intermediate aspartate semialdehyde. Production of this intermediate represents the first committed step in the biosynthesis of the essential amino acids methionine, isoleucine and threonine in fungi, and also the amino acid lysine in bacteria. The structure of a new fungal form of ASADH from Cryptococcus neoformans has been determined to 2.6 A resolution. The overall structure of CnASADH is similar to those of its bacterial orthologs, but with some critical differences both in biological assembly and in secondary-structural features that can potentially be exploited for the development of species-selective drugs. Structure of a fungal form of aspartate semialdehyde dehydrogenase from Cryptococcus neoformans.,Dahal G, Viola RE Acta Crystallogr F Struct Biol Commun. 2015 Nov 1;71(Pt 11):1365-71. doi:, 10.1107/S2053230X15017495. Epub 2015 Oct 23. PMID:26527262 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See Also Aspartate-semialdehyde dehydrogenase 3D structures

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