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==Crystal structure of Saccharomyces cerevisiae Gle1 CTD-Nup42 GBM complex==
==Crystal structure of Saccharomyces cerevisiae Gle1 CTD-Nup42 GBM complex==
<StructureSection load='6b4e' size='340' side='right' caption='[[6b4e]], [[Resolution|resolution]] 1.75&Aring;' scene=''>
<StructureSection load='6b4e' size='340' side='right'caption='[[6b4e]], [[Resolution|resolution]] 1.75&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[6b4e]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Baker's_yeast Baker's yeast]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6B4E OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6B4E FirstGlance]. <br>
<table><tr><td colspan='2'>[[6b4e]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_S288C Saccharomyces cerevisiae S288C]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6B4E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6B4E FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=PRO:PROLINE'>PRO</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.75&#8491;</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">GLE1, BRR3, RSS1, YDL207W, D1049 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=559292 Baker's yeast]), NUP42, RIP1, UIP1, YDR192C, YD9346.04C ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=559292 Baker's yeast])</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=PRO:PROLINE'>PRO</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6b4e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6b4e OCA], [http://pdbe.org/6b4e PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6b4e RCSB], [http://www.ebi.ac.uk/pdbsum/6b4e PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6b4e ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6b4e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6b4e OCA], [https://pdbe.org/6b4e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6b4e RCSB], [https://www.ebi.ac.uk/pdbsum/6b4e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6b4e ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/GLE1_YEAST GLE1_YEAST]] Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. It is specifically involved in a terminal step of poly(A)+ mRNA transport through the NPC probably by binding the ATP-dependent RNA helicase DBP5 and GFD1 at the cytoplasmic side of the NPC. These interactions are thought to be important for the dissociation of transport proteins such as the heterogeneous nuclear ribonuleoprotein (hnRNP) NAB2 from exported mRNA.<ref>PMID:10523319</ref> <ref>PMID:10610322</ref> <ref>PMID:10684247</ref> <ref>PMID:11336711</ref> <ref>PMID:15208322</ref> [[http://www.uniprot.org/uniprot/NUP42_YEAST NUP42_YEAST]] Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. Active directional transport is assured by both, a Phe-Gly (FG) repeat affinity gradient for these transport factors across the NPC and a transport cofactor concentration gradient across the nuclear envelope (GSP1 and GSP2 GTPases associated predominantly with GTP in the nucleus, with GDP in the cytoplasm). NUP42 is specifically important for nuclear protein and mRNA export.<ref>PMID:10523319</ref> <ref>PMID:10610322</ref> <ref>PMID:10805742</ref> <ref>PMID:10952996</ref> <ref>PMID:11387327</ref> <ref>PMID:12604785</ref> <ref>PMID:12917401</ref> <ref>PMID:15039779</ref> 
[https://www.uniprot.org/uniprot/GLE1_YEAST GLE1_YEAST] Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. It is specifically involved in a terminal step of poly(A)+ mRNA transport through the NPC probably by binding the ATP-dependent RNA helicase DBP5 and GFD1 at the cytoplasmic side of the NPC. These interactions are thought to be important for the dissociation of transport proteins such as the heterogeneous nuclear ribonuleoprotein (hnRNP) NAB2 from exported mRNA.<ref>PMID:10523319</ref> <ref>PMID:10610322</ref> <ref>PMID:10684247</ref> <ref>PMID:11336711</ref> <ref>PMID:15208322</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 6b4e" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 6b4e" style="background-color:#fffaf0;"></div>
==See Also==
*[[Nucleoporin 3D structures|Nucleoporin 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Baker's yeast]]
[[Category: Large Structures]]
[[Category: Cai, S W]]
[[Category: Saccharomyces cerevisiae S288C]]
[[Category: Correia, A R]]
[[Category: Cai SW]]
[[Category: Hoelz, A]]
[[Category: Correia AR]]
[[Category: Huber, F M]]
[[Category: Hoelz A]]
[[Category: Jette, C A]]
[[Category: Huber FM]]
[[Category: Lin, D H]]
[[Category: Jette CA]]
[[Category: Complex]]
[[Category: Lin DH]]
[[Category: Dead-box helicase]]
[[Category: Mrna export]]
[[Category: Nuclear pore complex]]
[[Category: Transport protein]]
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